Multiple drug delivery hydrogel system for spinal cord injury repair strategies

Giuseppe Perale, Filippo Rossi, Marco Santoro, Marco Peviani, Simonetta Papa, Dorina Llupi, Paola Torriani, Edoardo Micotti, Sara Previdi, Luigi Cervo, Erik Sundström, Aldo R. Boccaccini, Maurizio Masi, Gianluigi Forloni, Pietro Veglianese

Research output: Contribution to journalArticle

Abstract

The multifactorial pathological progress of spinal cord injury (SCI) is probably the main reason behind the absence of efficient therapeutic approaches. Hence, very recent highlights suggest the use of new multidrug delivery systems capable of local controlled release of therapeutic agents. In this work, a biocompatible hydrogel-based system was developed as multiple drug delivery tool, specifically designed for SCI repair strategies. Multiple release profiles were achieved by loading gel with a combination of low and high steric hindrance molecules. In vitro, in vivo and ex vivo release studies showed an independent combination of fast diffusion-controlled kinetics for smaller molecules together with slow diffusion-controlled kinetics for bigger ones. A preserved functionality of loaded substances was always achieved, confirming the absence of any chemical stable interactions between gel matrix and loaded molecules. Moreover, the relevant effect of the cerebrospinal fluid flux dynamics on the drug diffusion in the spinal cord tissue was here revealed for the first time: an oriented delivery of the released molecules in the spinal cord tract caudally to the gel site is demonstrated, thus suggesting a more efficient gel positioning rostrally to the lesion.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalJournal of Controlled Release
Volume159
Issue number2
DOIs
Publication statusPublished - Apr 30 2012

Keywords

  • Drug release
  • Hydrogel
  • Polymer
  • Spinal cord injury

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Perale, G., Rossi, F., Santoro, M., Peviani, M., Papa, S., Llupi, D., Torriani, P., Micotti, E., Previdi, S., Cervo, L., Sundström, E., Boccaccini, A. R., Masi, M., Forloni, G., & Veglianese, P. (2012). Multiple drug delivery hydrogel system for spinal cord injury repair strategies. Journal of Controlled Release, 159(2), 271-280. https://doi.org/10.1016/j.jconrel.2011.12.025