Multiple endocrine cell types in thyroid medullary carcinoma - Evidence for calcitonin, somatostatin, ACTH, 5HT and small granule cells

Carlo Capella, Cesare Bordi, Guido Monga, Roberto Buffa, Paolo Fontana, Silvana Bonfanti, Gianni Bussolati, Enrico Solcia

Research output: Contribution to journalArticle

Abstract

10 cases of thyroid medullary carcinoma (TMC) have been studied ultrastructurally and histochemically. Well differentiated calcitonin-producing C cells were present in all tumours, being prevalent in 9 cases. 5-Hydroxytryptamine (5HT) storing cells were found in two cases, somatostatin immunoreactive cells in at least 5 cases and ACTH-immunoreactive cells in 4 cases. Ultrastructurally, at least 3 types of apparently non-C cells were observed. Type 1 cells with large, poorly osmiophilic granules resembling those of gastroenteropancreatic D cells, were present in 6 cases; they appeared to correlate well with somatostatin immunoreactive cells. Type 2 cells with large osmiophilic granules were found in 5 cases; they resembled ACTH-MSH cells of the human pituitary and may correspond to the ACTH-immunoreactive cells of light microscopy. Type 3 cells with small granules and an unknown function were found in 6 cases, always in scarce number. It is concluded that TMC, although mainly made up of C cells, usually contains large proportions of other endocrine cell types.

Original languageEnglish
Pages (from-to)111-128
Number of pages18
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume377
Issue number2
DOIs
Publication statusPublished - Jun 1978

Keywords

  • 5HT cells
  • ACTH cells
  • Calcitonin cells
  • Somatostatin cells
  • Thyroid medullary carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy
  • Medicine(all)

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