Multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis: Description of a new family

Furio Pacini, L. Fugazzola, G. Bevilacqua, P. Viacava, V. Nardini, E. Martino

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple endocrine neoplasia (MEN) 2A associated to cutaneous lichen amyloidosis is a variant of MEN 2A recently reported in few families. We describe an additional family with this syndrome. The skin lesion is a pruritic one, located over the upper back showing, at biopsy, cutaneous amyloid. The propositus of our family was a 35-year-old woman already treated with total thyroidectomy for medullary thyroid cancer and with bilateral adrenalectomy for pheochromocytoma. The patient referred that the skin lesion was present since childhood and increased with time. Skin biopsy showed negative staining for amyloid, for calcitonin and neuron-specific enolase. The paraspinal muscles corresponding to the area of affected skin showed slight neurogenic abnormalities. Ten other members of her family were affected by MEN 2A, three of whom (all females) had the same cutaneous alteration.

Original languageEnglish
Pages (from-to)295-296
Number of pages2
JournalJournal of Endocrinological Investigation
Volume16
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • amyloid
  • cutaneous lichen amyloidosis
  • medullary thyroid cancer
  • Multiple endocrine neoplasia
  • pheochromocytoma

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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