Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

Federico V. Pallardó, Paolo Degan, Marco d'ischia, Frank J. Kelly, Adriana Zatterale, Rita Calzone, Giuseppe Castello, Rafael Fernandez-Delgado, Christina Dunster, Ana Lloret, Paola Manini, Maria Antonietta Pisanti, Emilia Vuttariello, Giovanni Pagano

Research output: Contribution to journalArticle

Abstract

Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalBiogerontology
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 2006

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Keywords

  • 8-hydroxy-2′-deoxyguanosine
  • Down syndrome
  • Glutathione
  • Glyoxal
  • Methylglyoxal
  • Plasmaantioxidants
  • Pro-oxidant state

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Pallardó, F. V., Degan, P., d'ischia, M., Kelly, F. J., Zatterale, A., Calzone, R., Castello, G., Fernandez-Delgado, R., Dunster, C., Lloret, A., Manini, P., Pisanti, M. A., Vuttariello, E., & Pagano, G. (2006). Multiple evidence for an early age pro-oxidant state in Down Syndrome patients. Biogerontology, 7(4), 211-220. https://doi.org/10.1007/s10522-006-9002-5