Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

Federico V. Pallardó, Paolo Degan, Marco d'ischia, Frank J. Kelly, Adriana Zatterale, Rita Calzone, Giuseppe Castello, Rafael Fernandez-Delgado, Christina Dunster, Ana Lloret, Paola Manini, Maria Antonietta Pisanti, Emilia Vuttariello, Giovanni Pagano

Research output: Contribution to journalArticlepeer-review


Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (

Original languageEnglish
Pages (from-to)211-220
Number of pages10
Issue number4
Publication statusPublished - Aug 2006


  • 8-hydroxy-2′-deoxyguanosine
  • Down syndrome
  • Glutathione
  • Glyoxal
  • Methylglyoxal
  • Plasmaantioxidants
  • Pro-oxidant state

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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