Abstract
Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (
| Original language | English |
|---|---|
| Pages (from-to) | 211-220 |
| Number of pages | 10 |
| Journal | Biogerontology |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2006 |
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Keywords
- 8-hydroxy-2′-deoxyguanosine
- Down syndrome
- Glutathione
- Glyoxal
- Methylglyoxal
- Plasmaantioxidants
- Pro-oxidant state
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Multiple evidence for an early age pro-oxidant state in Down Syndrome patients. / Pallardó, Federico V.; Degan, Paolo; d'ischia, Marco; Kelly, Frank J.; Zatterale, Adriana; Calzone, Rita; Castello, Giuseppe; Fernandez-Delgado, Rafael; Dunster, Christina; Lloret, Ana; Manini, Paola; Pisanti, Maria Antonietta; Vuttariello, Emilia; Pagano, Giovanni.
In: Biogerontology, Vol. 7, No. 4, 08.2006, p. 211-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple evidence for an early age pro-oxidant state in Down Syndrome patients
AU - Pallardó, Federico V.
AU - Degan, Paolo
AU - d'ischia, Marco
AU - Kelly, Frank J.
AU - Zatterale, Adriana
AU - Calzone, Rita
AU - Castello, Giuseppe
AU - Fernandez-Delgado, Rafael
AU - Dunster, Christina
AU - Lloret, Ana
AU - Manini, Paola
AU - Pisanti, Maria Antonietta
AU - Vuttariello, Emilia
AU - Pagano, Giovanni
PY - 2006/8
Y1 - 2006/8
N2 - Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (
AB - Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (
KW - 8-hydroxy-2′-deoxyguanosine
KW - Down syndrome
KW - Glutathione
KW - Glyoxal
KW - Methylglyoxal
KW - Plasmaantioxidants
KW - Pro-oxidant state
UR - http://www.scopus.com/inward/record.url?scp=33747256270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747256270&partnerID=8YFLogxK
U2 - 10.1007/s10522-006-9002-5
DO - 10.1007/s10522-006-9002-5
M3 - Article
VL - 7
SP - 211
EP - 220
JO - Biogerontology
JF - Biogerontology
SN - 1389-5729
IS - 4
ER -