Abstract
Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (
Original language | English |
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Pages (from-to) | 211-220 |
Number of pages | 10 |
Journal | Biogerontology |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2006 |
Keywords
- 8-hydroxy-2′-deoxyguanosine
- Down syndrome
- Glutathione
- Glyoxal
- Methylglyoxal
- Plasmaantioxidants
- Pro-oxidant state
ASJC Scopus subject areas
- Geriatrics and Gerontology