Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

Federico V. Pallardó; Paolo Degan; Marco d'ischia; Frank J. Kelly; Adriana Zatterale; Rita Calzone; Giuseppe Castello; Rafael Fernandez-Delgado; Christina Dunster; Ana Lloret; Paola Manini; Maria Antonietta Pisanti; Emilia Vuttariello; Giovanni Pagano

doi:10.1007/s10522-006-9002-5

Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

Federico V. Pallardó, Paolo Degan, Marco d'ischia, Frank J. Kelly, Adriana Zatterale, Rita Calzone, Giuseppe Castello, Rafael Fernandez-Delgado, Christina Dunster, Ana Lloret, Paola Manini, Maria Antonietta Pisanti, Emilia Vuttariello, Giovanni Pagano

Research output: Contribution to journal › Article › peer-review

Abstract

Oxidative stress has been associated with Down syndrome (DS) and with its major phenotypic features, such as early ageing. In order to evaluate an in vivo pro-oxidant state, the following analytes were measured in a group of DS patients aged 2 months to 57 years: (a) leukocyte 8-hydroxy-2′-deoxyguanosine (8-OHdG); (b) blood glutathione; (c) plasma levels of: glyoxal (Glx) and methylglyoxal (MGlx); some antioxidants (uric acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase (XO) activity. A significant 1.5-fold increase in 8-OHdG levels was observed in 28 DS patients vs. 63 controls, with a sharper increase in DS patients aged up to 30 years. The GSSG:GSH × 100 ratio was significantly higher in young DS patients (

Original language	English
Pages (from-to)	211-220
Number of pages	10
Journal	Biogerontology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1007/s10522-006-9002-5
Publication status	Published - Aug 2006

Keywords

8-hydroxy-2′-deoxyguanosine
Down syndrome
Glutathione
Glyoxal
Methylglyoxal
Plasmaantioxidants
Pro-oxidant state

ASJC Scopus subject areas

Geriatrics and Gerontology

Access to Document

10.1007/s10522-006-9002-5

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Multiple evidence for an early age pro-oxidant state in Down Syndrome patients. / Pallardó, Federico V.; Degan, Paolo; d'ischia, Marco; Kelly, Frank J.; Zatterale, Adriana; Calzone, Rita; Castello, Giuseppe; Fernandez-Delgado, Rafael; Dunster, Christina; Lloret, Ana; Manini, Paola; Pisanti, Maria Antonietta; Vuttariello, Emilia; Pagano, Giovanni.

In: Biogerontology, Vol. 7, No. 4, 08.2006, p. 211-220.

Research output: Contribution to journal › Article › peer-review

Pallardó, Federico V. ; Degan, Paolo ; d'ischia, Marco ; Kelly, Frank J. ; Zatterale, Adriana ; Calzone, Rita ; Castello, Giuseppe ; Fernandez-Delgado, Rafael ; Dunster, Christina ; Lloret, Ana ; Manini, Paola ; Pisanti, Maria Antonietta ; Vuttariello, Emilia ; Pagano, Giovanni. / Multiple evidence for an early age pro-oxidant state in Down Syndrome patients. In: Biogerontology. 2006 ; Vol. 7, No. 4. pp. 211-220.

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