Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome

A. F. Radicioni; G. Di Giorgio; G. Grugni; M. Cuttini; V. Losacco; A. Anzuini; S. Spera; C. Marzano; A. Lenzi; M. Cappa; A. Crinò

doi:10.1111/j.1365-2265.2011.04161.x

Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome

A. F. Radicioni, G. Di Giorgio, G. Grugni, M. Cuttini, V. Losacco, A. Anzuini, S. Spera, C. Marzano, A. Lenzi, M. Cappa, A. Crinò

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Abstract

Background Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. Objectives To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B and sexhormone-binding globulin (SHBG) were performed in 34 PWS patients, age 5·1-42·7 years, and in 125 healthy males of same age range. All participants were divided into two groups: <or ≥13·5 years. Results Pubertal PWS patients showed an arrest of pubertal development. Patients

Original language	English
Pages (from-to)	72-77
Number of pages	6
Journal	Clinical Endocrinology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2265.2011.04161.x
Publication status	Published - Jan 2012

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ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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Radicioni, A. F., Di Giorgio, G., Grugni, G., Cuttini, M., Losacco, V., Anzuini, A., Spera, S., Marzano, C., Lenzi, A., Cappa, M., & Crinò, A. (2012). Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome. Clinical Endocrinology, 76(1), 72-77. https://doi.org/10.1111/j.1365-2265.2011.04161.x

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abstract = "Background Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. Objectives To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B and sexhormone-binding globulin (SHBG) were performed in 34 PWS patients, age 5·1-42·7 years, and in 125 healthy males of same age range. All participants were divided into two groups: ",

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AU - Radicioni, A. F.

AU - Di Giorgio, G.

AU - Grugni, G.

AU - Cuttini, M.

AU - Losacco, V.

AU - Anzuini, A.

AU - Spera, S.

AU - Marzano, C.

AU - Lenzi, A.

AU - Cappa, M.

AU - Crinò, A.

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10.1111/j.1365-2265.2011.04161.x