TY - JOUR
T1 - Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome
AU - Radicioni, A. F.
AU - Di Giorgio, G.
AU - Grugni, G.
AU - Cuttini, M.
AU - Losacco, V.
AU - Anzuini, A.
AU - Spera, S.
AU - Marzano, C.
AU - Lenzi, A.
AU - Cappa, M.
AU - Crinò, A.
PY - 2012/1
Y1 - 2012/1
N2 - Background Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. Objectives To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B and sexhormone-binding globulin (SHBG) were performed in 34 PWS patients, age 5·1-42·7 years, and in 125 healthy males of same age range. All participants were divided into two groups:
AB - Background Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. Objectives To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B and sexhormone-binding globulin (SHBG) were performed in 34 PWS patients, age 5·1-42·7 years, and in 125 healthy males of same age range. All participants were divided into two groups:
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U2 - 10.1111/j.1365-2265.2011.04161.x
DO - 10.1111/j.1365-2265.2011.04161.x
M3 - Article
C2 - 21718342
AN - SCOPUS:83455200230
VL - 76
SP - 72
EP - 77
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 1
ER -