Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome

A. F. Radicioni, G. Di Giorgio, G. Grugni, M. Cuttini, V. Losacco, A. Anzuini, S. Spera, C. Marzano, A. Lenzi, M. Cappa, A. Crinò

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Abstract

Background Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect, but pathophysiology is still unclear. Objectives To investigate the aetiology of hypothalamic-pituitary-gonadal axis dysfunction in PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, inhibin B and sexhormone-binding globulin (SHBG) were performed in 34 PWS patients, age 5·1-42·7 years, and in 125 healthy males of same age range. All participants were divided into two groups: <or ≥13·5 years. Results Pubertal PWS patients showed an arrest of pubertal development. Patients

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalClinical Endocrinology
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 2012

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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