Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma

Carmela De Marco, Nicola Rinaldo, Paola Bruni, Carmine Malzoni, Fulvio Zullo, Fernanda Fabiani, Simona Losito, Marianna Scrima, Federica Zito Marino, Renato Franco, Alfina Quintiero, Valter Agosti, Giuseppe Viglietto

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Abstract

The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is activated in multiple cancers including ovarian carcinoma (OC). However, the relative contribution of the single components within the PI3K pathway to AKT activation in OC is still unclear. We examined 98 tumor samples from Italian OC patients for alterations in the members of the PI3K pathway. We report that AKT is significantly hyperactive in OC compared to normal tissue (n = 93; p58 years old; n = 93; p

Original languageEnglish
Article numbere55362
JournalPLoS One
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 7 2013

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

De Marco, C., Rinaldo, N., Bruni, P., Malzoni, C., Zullo, F., Fabiani, F., Losito, S., Scrima, M., Marino, F. Z., Franco, R., Quintiero, A., Agosti, V., & Viglietto, G. (2013). Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma. PLoS One, 8(2), [e55362]. https://doi.org/10.1371/journal.pone.0055362