Abstract
In recent years, significant progress has been made in identifying characteristic chromosomal and molecular rearrangements associated with several solid tumors. Most solid tumors studied have been found to be characterized by recurrent chromosomal abnormalities that are specific to histological types. We have studied primary specimens of malignant melanoma, gastrointestinal cancer, renal carcinoma, lung and ovarian cancer, by cytogenetic and molecular means, and we discuss the genetic alterations found. Brief descriptions of the potential clinical utility, and biological relevance changes in these disorders are also discussed.
Original language | English |
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Pages (from-to) | 2943-2953 |
Number of pages | 11 |
Journal | Anticancer Research |
Volume | 16 |
Issue number | 5 A |
Publication status | Published - Sep 1996 |
Keywords
- C-MYB
- Chromosomal abnormalities
- DCC
- Gastrointestinal cancer
- Lung cancer
- Malignant melanoma
- MTS1
- NM23
- Ovarian cancer
- p53
- PTPRG
- Renal carcinoma
ASJC Scopus subject areas
- Cancer Research
- Oncology