Multiple genetic lesions in solid tumors: Relevance to diagnosis, prognosis, and molecular mechanisms

Graziella Cimino Reale, Rocco Urso, Irene Venturo, Daniela Lombardi, Rita Gasbarra, Fabio M. Sega, Cosimo Barletta

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, significant progress has been made in identifying characteristic chromosomal and molecular rearrangements associated with several solid tumors. Most solid tumors studied have been found to be characterized by recurrent chromosomal abnormalities that are specific to histological types. We have studied primary specimens of malignant melanoma, gastrointestinal cancer, renal carcinoma, lung and ovarian cancer, by cytogenetic and molecular means, and we discuss the genetic alterations found. Brief descriptions of the potential clinical utility, and biological relevance changes in these disorders are also discussed.

Original languageEnglish
Pages (from-to)2943-2953
Number of pages11
JournalAnticancer Research
Volume16
Issue number5 A
Publication statusPublished - Sep 1996

Keywords

  • C-MYB
  • Chromosomal abnormalities
  • DCC
  • Gastrointestinal cancer
  • Lung cancer
  • Malignant melanoma
  • MTS1
  • NM23
  • Ovarian cancer
  • p53
  • PTPRG
  • Renal carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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