Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice

G. Manenti, G. Binelli, M. Gariboldi, F. Canzian, L. De Gregorio, F. S. Falvella, T. A. Dragani, M. A. Pierotti

Research output: Contribution to journalArticle

Abstract

The C3H/He mouse represents a good experimental model of genetic predisposition to hepatocellular tumor development. We analyzed an interspecific test-cross population of 106 urethane-treated male (C3H/He x Mus spretus) x C57BL/6J mice, typed with 222 genetic markers to locate precisely the hepatocellular tumor susceptibility (Hcs) loci. Three regions, on chromosomes 2, 5, and 19, showed a significant linkage with hepatocellular tumor development, as indicated by different quantitative indexes estimating liver tumor size. Liver tumor frequency was not genetically controlled. These loci are different from three other Hcs loci that we have previously mapped in an F2 progeny of the C3H/He mouse crossed with the resistant laboratory strain A/J. The present result indicates a multigenic model of inheritance for hepatocellular tumor susceptibility.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalGenomics
Volume23
Issue number1
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Genetics

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