TY - GEN
T1 - Multiple mechanisms for hydrogen peroxide-induced apoptosis
AU - Cerella, Claudia
AU - Coppola, Simona
AU - Maresca, Vittoria
AU - De Nicola, Milena
AU - Radogna, Flavia
AU - Ghibelli, Lina
PY - 2009/8
Y1 - 2009/8
N2 - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.
AB - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.
KW - ADP-ribosylation
KW - Apoptosis
KW - Hydrogen peroxide
UR - http://www.scopus.com/inward/record.url?scp=69149103207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69149103207&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04901.x
DO - 10.1111/j.1749-6632.2009.04901.x
M3 - Conference contribution
C2 - 19723104
AN - SCOPUS:69149103207
SN - 9781573317375
VL - 1171
T3 - Annals of the New York Academy of Sciences
SP - 559
EP - 563
BT - Annals of the New York Academy of Sciences
ER -