Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella, Simona Coppola, Vittoria Maresca, Milena De Nicola, Flavia Radogna, Lina Ghibelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages559-563
Number of pages5
Volume1171
DOIs
Publication statusPublished - Aug 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1171
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Oxidative stress
Hydrogen Peroxide
Oxidative Stress
Apoptosis
Recovery
DNA Breaks
Cells
DNA

Keywords

  • ADP-ribosylation
  • Apoptosis
  • Hydrogen peroxide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cerella, C., Coppola, S., Maresca, V., De Nicola, M., Radogna, F., & Ghibelli, L. (2009). Multiple mechanisms for hydrogen peroxide-induced apoptosis. In Annals of the New York Academy of Sciences (Vol. 1171, pp. 559-563). (Annals of the New York Academy of Sciences; Vol. 1171). https://doi.org/10.1111/j.1749-6632.2009.04901.x

Multiple mechanisms for hydrogen peroxide-induced apoptosis. / Cerella, Claudia; Coppola, Simona; Maresca, Vittoria; De Nicola, Milena; Radogna, Flavia; Ghibelli, Lina.

Annals of the New York Academy of Sciences. Vol. 1171 2009. p. 559-563 (Annals of the New York Academy of Sciences; Vol. 1171).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cerella, C, Coppola, S, Maresca, V, De Nicola, M, Radogna, F & Ghibelli, L 2009, Multiple mechanisms for hydrogen peroxide-induced apoptosis. in Annals of the New York Academy of Sciences. vol. 1171, Annals of the New York Academy of Sciences, vol. 1171, pp. 559-563. https://doi.org/10.1111/j.1749-6632.2009.04901.x
Cerella C, Coppola S, Maresca V, De Nicola M, Radogna F, Ghibelli L. Multiple mechanisms for hydrogen peroxide-induced apoptosis. In Annals of the New York Academy of Sciences. Vol. 1171. 2009. p. 559-563. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.04901.x
Cerella, Claudia ; Coppola, Simona ; Maresca, Vittoria ; De Nicola, Milena ; Radogna, Flavia ; Ghibelli, Lina. / Multiple mechanisms for hydrogen peroxide-induced apoptosis. Annals of the New York Academy of Sciences. Vol. 1171 2009. pp. 559-563 (Annals of the New York Academy of Sciences).
@inproceedings{0beec9ba6a724446baa8c2714bfe66e8,
title = "Multiple mechanisms for hydrogen peroxide-induced apoptosis",
abstract = "The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.",
keywords = "ADP-ribosylation, Apoptosis, Hydrogen peroxide",
author = "Claudia Cerella and Simona Coppola and Vittoria Maresca and {De Nicola}, Milena and Flavia Radogna and Lina Ghibelli",
year = "2009",
month = "8",
doi = "10.1111/j.1749-6632.2009.04901.x",
language = "English",
isbn = "9781573317375",
volume = "1171",
series = "Annals of the New York Academy of Sciences",
pages = "559--563",
booktitle = "Annals of the New York Academy of Sciences",

}

TY - GEN

T1 - Multiple mechanisms for hydrogen peroxide-induced apoptosis

AU - Cerella, Claudia

AU - Coppola, Simona

AU - Maresca, Vittoria

AU - De Nicola, Milena

AU - Radogna, Flavia

AU - Ghibelli, Lina

PY - 2009/8

Y1 - 2009/8

N2 - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

AB - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

KW - ADP-ribosylation

KW - Apoptosis

KW - Hydrogen peroxide

UR - http://www.scopus.com/inward/record.url?scp=69149103207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69149103207&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2009.04901.x

DO - 10.1111/j.1749-6632.2009.04901.x

M3 - Conference contribution

C2 - 19723104

AN - SCOPUS:69149103207

SN - 9781573317375

VL - 1171

T3 - Annals of the New York Academy of Sciences

SP - 559

EP - 563

BT - Annals of the New York Academy of Sciences

ER -