Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella, Simona Coppola, Vittoria Maresca, Milena De Nicola, Flavia Radogna, Lina Ghibelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages559-563
Number of pages5
Volume1171
DOIs
Publication statusPublished - Aug 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1171
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • ADP-ribosylation
  • Apoptosis
  • Hydrogen peroxide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Cerella, C., Coppola, S., Maresca, V., De Nicola, M., Radogna, F., & Ghibelli, L. (2009). Multiple mechanisms for hydrogen peroxide-induced apoptosis. In Annals of the New York Academy of Sciences (Vol. 1171, pp. 559-563). (Annals of the New York Academy of Sciences; Vol. 1171). https://doi.org/10.1111/j.1749-6632.2009.04901.x