Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella; Simona Coppola; Vittoria Maresca; Milena De Nicola; Flavia Radogna; Lina Ghibelli

doi:10.1111/j.1749-6632.2009.04901.x

Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella, Simona Coppola, Vittoria Maresca, Milena De Nicola, Flavia Radogna, Lina Ghibelli

Istituto S. Maria e S. Gallicano

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H₂O₂ treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H ₂O₂-induced mitochondrial alterations.

Original language	English
Title of host publication	Annals of the New York Academy of Sciences
Pages	559-563
Number of pages	5
Volume	1171
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04901.x
Publication status	Published - Aug 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1171
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

ADP-ribosylation
Apoptosis
Hydrogen peroxide

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1111/j.1749-6632.2009.04901.x

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Multiple mechanisms for hydrogen peroxide-induced apoptosis. / Cerella, Claudia; Coppola, Simona; Maresca, Vittoria; De Nicola, Milena; Radogna, Flavia; Ghibelli, Lina.

Annals of the New York Academy of Sciences. Vol. 1171 2009. p. 559-563 (Annals of the New York Academy of Sciences; Vol. 1171).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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