Multiple mechanisms of iron-induced ferritin synthesis in HeLa cells

Gaetano Cairo, Lidia Bardella, Luisa Schiaffonati, Paolo Arosio, Sonia Levi, Aldo Bernelli-Zazzera

Research output: Contribution to journalArticlepeer-review

Abstract

Iron administration to HeLa cells stimulates the accumulation of H-sub unit and L-subunit rich isoferritins at similar extent. The increase in both types of isoferritins is accompanied by an increase in the amount of messenger RNAs specific for H and L subunits. The increase in the amount of these messenger RNAs, which occurs in the nucleus as well as in the cytoplasm, is proportionately lower than the increase in the protein. These results, together with analysis of transcription in isolated nuclei indicate the existence of a mechanism of transcriptional control of ferritin synthesis, associated to the translational control described so far.

Original languageEnglish
Pages (from-to)314-321
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume133
Issue number1
DOIs
Publication statusPublished - Nov 27 1985

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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