Multiple myeloma as a model for the role of bone marrow niches in the control of angiogenesis

Domenico Ribatti, Beatrice Nico, Angelo Vacca

Research output: Contribution to journalArticlepeer-review


Bone marrow (BM) contains hematopoietic stem cells (HSCs) and nonhematopoietic cells. HSCs give rise to all types of mature blood cells, while the nonhematopoietic component includes osteoblasts/osteoclasts, endothelial cells (ECs), endothelial progenitor cells (EPCs), and mesenchymal stem cells (MSCs). These cells form specialized "niches" which are closeto the vasculature ("vascular niche") or to the endosteum ("osteoblast niche"). The "vascular niche", rich in blood vessels where ECs and muralcells (pericytes and smooth muscle cells), create a microenvironment affectingthe behavior of several stem and progenitor cells. The vessel wall acts as an independent niche for the recruitment of EPCs and MSCs. This chapter will focus on the description of the role of BM niches in the control of angiogenesis occurring during multiple myeloma progression.

Original languageEnglish
Pages (from-to)259-282
Number of pages24
JournalInternational Review of Cell and Molecular Biology
Publication statusPublished - 2015


  • Angiogenesis
  • Multiple myeloma
  • Osteoblastic niche
  • Tumor growth
  • Vascular niche

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biochemistry
  • Medicine(all)


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