Multiple myeloma: Comparison of two dose-intensive melphalan regimens (100 vs 200 mg/m2)

A. Palumbo; S. Bringhen; A. Bertola; F. Cavallo; P. Falco; M. Massaia; B. Bruno; C. Rus; A. Barbui; T. Caravita; P. Musto; N. Pescota; F. Rossini; M. Vignetti; Mario Boccadoro

doi:10.1038/sj.leu.2403196

Multiple myeloma: Comparison of two dose-intensive melphalan regimens (100 vs 200 mg/m2)

A. Palumbo, S. Bringhen, A. Bertola, F. Cavallo, P. Falco, M. Massaia, B. Bruno, C. Rus, A. Barbui, T. Caravita, P. Musto, N. Pescota, F. Rossini, M. Vignetti, Mario Boccadoro

IRCCS Centro di Riferimento Oncologico della Basilicata (CROB)

Research output: Contribution to journal › Article › peer-review

Abstract

Several trials have shown the superior impact of high-dose melphalan (usually 200mg/m², MEL200) vs standard therapy in myeloma patients. Intermediate-dose melphalan (100mg/m², MEL100) is also superior to the standard dose, but has not been clinically compared with MEL200. A total of 90 patients at diagnosis were treated with two MEL100 courses. Their clinical outcome was compared with that of a control group of 90 pair mates matched for serum β2-microglobulin levels and Durie and Salmon clinical stage. These patients were treated at diagnosis with two MEL200 courses. Patient characteristics were similar in both groups except that the median age of the MEL100 group was significantly higher (P

Original language	English
Pages (from-to)	133-138
Number of pages	6
Journal	Leukemia
Volume	18
Issue number	1
DOIs	https://doi.org/10.1038/sj.leu.2403196
Publication status	Published - Jan 2004

Keywords

Dose-intensive
Melphalan
Myelomatransplantation

ASJC Scopus subject areas

Hematology
Cancer Research

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10.1038/sj.leu.2403196

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Multiple myeloma : Comparison of two dose-intensive melphalan regimens (100 vs 200 mg/m2). / Palumbo, A.; Bringhen, S.; Bertola, A.; Cavallo, F.; Falco, P.; Massaia, M.; Bruno, B.; Rus, C.; Barbui, A.; Caravita, T.; Musto, P.; Pescota, N.; Rossini, F.; Vignetti, M.; Boccadoro, Mario.

In: Leukemia, Vol. 18, No. 1, 01.2004, p. 133-138.

Research output: Contribution to journal › Article › peer-review

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AU - Falco, P.

AU - Massaia, M.

AU - Bruno, B.

AU - Rus, C.

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AB - Several trials have shown the superior impact of high-dose melphalan (usually 200mg/m2, MEL200) vs standard therapy in myeloma patients. Intermediate-dose melphalan (100mg/m2, MEL100) is also superior to the standard dose, but has not been clinically compared with MEL200. A total of 90 patients at diagnosis were treated with two MEL100 courses. Their clinical outcome was compared with that of a control group of 90 pair mates matched for serum β2-microglobulin levels and Durie and Salmon clinical stage. These patients were treated at diagnosis with two MEL200 courses. Patient characteristics were similar in both groups except that the median age of the MEL100 group was significantly higher (P

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Multiple myeloma: Comparison of two dose-intensive melphalan regimens (100 vs 200 mg/m2)

Abstract

Keywords

ASJC Scopus subject areas

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