Multiple primary malignant melanoma (MPMM): Cytogenetic study

P. Grammatico, M. Roccella, P. Muratore, G. Pennesi, F. Roccella, C. Catricalà, F. Del Porto, L. Eibenschutz, G. Del Porto

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple primary malignant melanoma (MPMM) is a rare condition that involves about 1-4% of patients affected by malignant melanomas. In order to contribute to a better definition of this kind of tumor we performed a cytogenetic study on three different lesions, from a female patient, classified by clinical and immunohistochemical parameters. Immunogenetic analysis was also performed on peripheral blood lymphocytes. The cytogenetic results allow us to evidence different clonal chromosomal rearrangements in two of the three lesions, confirming the policlonality of these three melanomas. The immunohistochemical results highlight the expression of the HLA-DR in the primary cell cultures showing chromosomal markers, considered by some authors as a negative prognostic factor. We are performing a clinical follow-up on the patient in order to evaluate the significance of these markers specifically with regards to the disease's evolution.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume15
Issue number4
Publication statusPublished - Dec 1996

Keywords

  • chromosome 10
  • chromosome 2
  • chromosome 7
  • FISH
  • multiple primary malignant melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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