Multiple risk factors in hypertension: Results from the Gubbio study

Martino Laurenzi, Mario Mancini, Alessandro Menotti, Jeremiah Stamler, Rose Stamler, Maurizio Trevisan, Alberto Zanchetti

Research output: Contribution to journalArticlepeer-review


The association between hypertension and a number of cardiovascular disease risk factors was assessed in the large population sample of Gubbio, a town in central Italy that dates back to medieval times. The data confirm those of previous studies showing that hypertension is strongly associated with other metabolic abnormalities, such as markedly overweight subjects, hyperuricaemia, hyperglycaemia, hypercholesterolaemia, that maybe related to the aetiopathogenesis of high blood pressure and, in addition, compound the risk of major clinical cardiovascular events in people with hypertension. The findings are therefore relevant for prevention strategies. In addition, the association between erythrocyte sodium-stimulated lithium countertransport and hypertension is being studied.

Original languageEnglish
Pages (from-to)S7-S12
JournalJournal of Hypertension
Publication statusPublished - 1990


  • Gubbio study
  • Hypercholesterolaemia
  • Hyperuricaemia
  • Metabolic abnormalities
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology


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