Multiple roles of Histamine in autoimmune demyelinating disease of the central nervous system

Massimo Costanza, Silvia Musio, Rosetta Pedotti

Research output: Contribution to journalArticle

Abstract

Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.

Original languageEnglish
Pages (from-to)418-426
Number of pages9
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Volume10
Issue number6
DOIs
Publication statusPublished - 2012

Fingerprint

CNS Demyelinating Autoimmune Diseases
Histamine
Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Biogenic Amines
Myelin Sheath
Central Nervous System
Animal Models
Cytokines
Inflammation
Antibodies

Keywords

  • Blood-brain barrier
  • Cytokines
  • Experimental autoimmune encephalomyelitis
  • Histamine
  • Multiple sclerosis
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Multiple roles of Histamine in autoimmune demyelinating disease of the central nervous system. / Costanza, Massimo; Musio, Silvia; Pedotti, Rosetta.

In: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, Vol. 10, No. 6, 2012, p. 418-426.

Research output: Contribution to journalArticle

@article{82f4843278884cd48e52dc4aed226d6b,
title = "Multiple roles of Histamine in autoimmune demyelinating disease of the central nervous system",
abstract = "Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.",
keywords = "Blood-brain barrier, Cytokines, Experimental autoimmune encephalomyelitis, Histamine, Multiple sclerosis, T cells",
author = "Massimo Costanza and Silvia Musio and Rosetta Pedotti",
year = "2012",
doi = "10.2174/1871523011109060418",
language = "English",
volume = "10",
pages = "418--426",
journal = "Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry",
issn = "1871-5230",
publisher = "Bentham Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - Multiple roles of Histamine in autoimmune demyelinating disease of the central nervous system

AU - Costanza, Massimo

AU - Musio, Silvia

AU - Pedotti, Rosetta

PY - 2012

Y1 - 2012

N2 - Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.

AB - Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.

KW - Blood-brain barrier

KW - Cytokines

KW - Experimental autoimmune encephalomyelitis

KW - Histamine

KW - Multiple sclerosis

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=84870160411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870160411&partnerID=8YFLogxK

U2 - 10.2174/1871523011109060418

DO - 10.2174/1871523011109060418

M3 - Article

AN - SCOPUS:84870160411

VL - 10

SP - 418

EP - 426

JO - Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

JF - Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

SN - 1871-5230

IS - 6

ER -