Multiple roles of Histamine in autoimmune demyelinating disease of the central nervous system

Massimo Costanza, Silvia Musio, Rosetta Pedotti

Research output: Contribution to journalArticlepeer-review


Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.

Original languageEnglish
Pages (from-to)418-426
Number of pages9
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Issue number6
Publication statusPublished - 2012


  • Blood-brain barrier
  • Cytokines
  • Experimental autoimmune encephalomyelitis
  • Histamine
  • Multiple sclerosis
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology


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