Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis

A. Catassi, D. Servent, L. Paleari, A. Cesario, P. Russo

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The genotoxic effects of tobacco carcinogens have long been recognized, the contribution of tobacco components to cancerogenesis by cell surface receptor signaling is relatively unexplored. Nicotine, the principal tobacco alkaloid, acts through nicotinic acetylcholine receptor (nAChR). nAChR are functionally present on human lung airway epithelial cells, on lung carcinoma [SCLC and NSCLC] and on mesothelioma and build a part of an autocrine-proliferative network that facilitates the growth of neoplastic cells. Different nAChR subunit gene expression patterns are expressed between NSCLC from smokers and non-smokers. Although there is no evidence that nicotine itself could induce cancer, different studies established that nicotine promotes in vivo the growth of cancer cells and the proliferation of endothelial cells suggesting that nicotine might contribute to the progression of tumors already initiated. These observations led to the hypothesis that nicotine might be playing a direct role in the promotion and progression of human lung cancers. Here, we briefly overview the role and the effects of nicotine on pulmonary cell growth and physiology and its feasible implications in lung carcinogenesis.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalMutation Research - Reviews in Mutation Research
Volume659
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Nicotine
Carcinogenesis
Cell Proliferation
Apoptosis
Lung
Nicotinic Receptors
Tobacco
Growth
Cell Physiological Phenomena
Neoplasms
Mesothelioma
Cell Surface Receptors
Alkaloids
Carcinogens
Lung Neoplasms
Endothelial Cells
Epithelial Cells
Carcinoma
Gene Expression

Keywords

  • Apoptosis
  • Cell proliferation
  • Human cancerogenesis
  • Lung cancer
  • Nicotine
  • Nicotinic receptor
  • Promotion

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis

Cite this

Multiple roles of nicotine on cell proliferation and inhibition of apoptosis : Implications on lung carcinogenesis. / Catassi, A.; Servent, D.; Paleari, L.; Cesario, A.; Russo, P.

In: Mutation Research - Reviews in Mutation Research, Vol. 659, No. 3, 09.2008, p. 221-231.

Research output: Contribution to journalArticle

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