Multiple Sclerosis

Julia Schaeffer, Chiara Cossetti, Giulia Mallucci, Stefano Pluchino

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelination disease of the human CNS that affects young adults and can, over subsequent decades, transform into a progressive neurodegenerative disorder associated with major clinical disabilities. MS is likely to emerge as a result of a complex combination of genetic factors, environmental triggers, and infectious events. MS lesions are thought to originate from an autoimmune disorder, where the immune system recognizes CNS myelin as foreign and is subsequently activated to destroy it. This leads to the formation of demyelinated plaques, which undergo at some point axonal damage and neurodegeneration. In addition to understanding the mechanisms underlying pathogenesis, one of the major challenges in MS research is to find therapies to prevent the permanent and irreversible neurological decline characterizing the chronic progressive phase of the disease, and to restore function.

Original languageEnglish
Title of host publicationNeurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders
PublisherElsevier Inc.
Pages497-520
Number of pages24
ISBN (Print)9780123982803, 9780123982704
DOIs
Publication statusPublished - Dec 3 2014

Keywords

  • Autoimmunity
  • Blood-brain barrier
  • Demyelination
  • Disease-modifying treatment
  • Immune modulation
  • Inflammation
  • Multiple sclerosis
  • Neuroimmunology
  • Remyelination
  • Stem cell

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Multiple Sclerosis'. Together they form a unique fingerprint.

  • Cite this

    Schaeffer, J., Cossetti, C., Mallucci, G., & Pluchino, S. (2014). Multiple Sclerosis. In Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders (pp. 497-520). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398270-4.00030-6