TY - JOUR
T1 - Multiple sclerosis
T2 - Altered thalamic resting-state functional connectivity and its effect on cognitive function
AU - Tona, Francesca
AU - Petsas, Nikolaos
AU - Sbardella, Emilia
AU - Prosperini, Luca
AU - Carmellini, Maurizio
AU - Pozzilli, Carlo
AU - Pantano, Patrizia
PY - 2014
Y1 - 2014
N2 - Purpose: To investigate, by using resting-state (RS) functional magnetic resonance (MR) imaging, thalamocortical functional connectivity (FC) and its correlations with cognitive impairment in multiple sclerosis (MS). Materials and Methods: All subjects provided written informed consent; the study protocol was approved by the university institutional review board for this HIPAA-compliant study. Forty-eight patients with relapsing-remitting MS and 24 control subjects underwent multimodal MR imaging, including diffusion-tensor imaging, three-dimensional (3D) T1-weighted imaging, and functional MR imaging at rest and a neuropsychological examination with the Paced Auditory Serial Addition Test (PASAT). Functional MR imaging data were analyzed with tools from FMRIB Software Library, by using the seed-based method to identify the thalamic RS network (RSN). Results: When compared with control subjects, patients showed gray matter and white matter atrophy, as well as diffusiontensor imaging abnormalities (P
AB - Purpose: To investigate, by using resting-state (RS) functional magnetic resonance (MR) imaging, thalamocortical functional connectivity (FC) and its correlations with cognitive impairment in multiple sclerosis (MS). Materials and Methods: All subjects provided written informed consent; the study protocol was approved by the university institutional review board for this HIPAA-compliant study. Forty-eight patients with relapsing-remitting MS and 24 control subjects underwent multimodal MR imaging, including diffusion-tensor imaging, three-dimensional (3D) T1-weighted imaging, and functional MR imaging at rest and a neuropsychological examination with the Paced Auditory Serial Addition Test (PASAT). Functional MR imaging data were analyzed with tools from FMRIB Software Library, by using the seed-based method to identify the thalamic RS network (RSN). Results: When compared with control subjects, patients showed gray matter and white matter atrophy, as well as diffusiontensor imaging abnormalities (P
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U2 - 10.1148/radiol.14131688
DO - 10.1148/radiol.14131688
M3 - Article
C2 - 24484065
AN - SCOPUS:84901649886
VL - 271
SP - 814
EP - 821
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -