Multiple sclerosis: Altered thalamic resting-state functional connectivity and its effect on cognitive function

Francesca Tona, Nikolaos Petsas, Emilia Sbardella, Luca Prosperini, Maurizio Carmellini, Carlo Pozzilli, Patrizia Pantano

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate, by using resting-state (RS) functional magnetic resonance (MR) imaging, thalamocortical functional connectivity (FC) and its correlations with cognitive impairment in multiple sclerosis (MS). Materials and Methods: All subjects provided written informed consent; the study protocol was approved by the university institutional review board for this HIPAA-compliant study. Forty-eight patients with relapsing-remitting MS and 24 control subjects underwent multimodal MR imaging, including diffusion-tensor imaging, three-dimensional (3D) T1-weighted imaging, and functional MR imaging at rest and a neuropsychological examination with the Paced Auditory Serial Addition Test (PASAT). Functional MR imaging data were analyzed with tools from FMRIB Software Library, by using the seed-based method to identify the thalamic RS network (RSN). Results: When compared with control subjects, patients showed gray matter and white matter atrophy, as well as diffusiontensor imaging abnormalities (P

Original languageEnglish
Pages (from-to)814-821
Number of pages8
JournalRadiology
Volume271
Issue number3
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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