Abstract
Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different central nervous system pathology that, according to the most accredited hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence of MS and ALS is quite unusual. To our knowledge, only three cases have been so far described by clinical, laboratory, and post-mortem studies. We report four new cases of this peculiar combination that have been observed and are herein described, included their human leukocyte antigen (HLA) profile studies. On the basis that three out of four patients in our case series presented HLA-B*18:01A, we may hypothesize that this antigen could play a role in developing both diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1501-1503 |
| Number of pages | 3 |
| Journal | Neurological Sciences |
| Volume | 38 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2017 |
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Keywords
- Journal Article
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Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen challenge. / Dattola, Vincenzo; Famà, Fausto; Russo, Margherita; Calabrò, Rocco Salvatore; Logiudice, Anna Lisa; Grasso, Maria Grazia; Patti, Francesco; Buccafusca, Maria.
In: Neurological Sciences, Vol. 38, No. 8, 08.2017, p. 1501-1503.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen challenge
AU - Dattola, Vincenzo
AU - Famà, Fausto
AU - Russo, Margherita
AU - Calabrò, Rocco Salvatore
AU - Logiudice, Anna Lisa
AU - Grasso, Maria Grazia
AU - Patti, Francesco
AU - Buccafusca, Maria
PY - 2017/8
Y1 - 2017/8
N2 - Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different central nervous system pathology that, according to the most accredited hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence of MS and ALS is quite unusual. To our knowledge, only three cases have been so far described by clinical, laboratory, and post-mortem studies. We report four new cases of this peculiar combination that have been observed and are herein described, included their human leukocyte antigen (HLA) profile studies. On the basis that three out of four patients in our case series presented HLA-B*18:01A, we may hypothesize that this antigen could play a role in developing both diseases.
AB - Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different central nervous system pathology that, according to the most accredited hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence of MS and ALS is quite unusual. To our knowledge, only three cases have been so far described by clinical, laboratory, and post-mortem studies. We report four new cases of this peculiar combination that have been observed and are herein described, included their human leukocyte antigen (HLA) profile studies. On the basis that three out of four patients in our case series presented HLA-B*18:01A, we may hypothesize that this antigen could play a role in developing both diseases.
KW - Journal Article
U2 - 10.1007/s10072-017-2939-0
DO - 10.1007/s10072-017-2939-0
M3 - Article
VL - 38
SP - 1501
EP - 1503
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 8
ER -