Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis

M. Saresella, A. Rolland, I. Marventano, R. Cavarretta, D. Caputo, P. Marche, H. Perron, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Human endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients. Objective and methods: We analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-α (P <0.05) and interferon-γ (P <0.004) in AMS patients and of interleukin-10 (P <0.05), an inflammation-dampening cytokine, in SMS individuals. Conclusions: These data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalMultiple Sclerosis Journal
Volume15
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Cytokines
  • ENV-SU protein
  • Human endogenous retroviruses (HERV)
  • Immunology
  • Multiple sclerosis
  • T lymphocytes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint

Dive into the research topics of 'Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis'. Together they form a unique fingerprint.

Cite this