Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation

Franca Tecchio, Andrea Cancelli, Carlo Cottone, Giancarlo Zito, Patrizio Pasqualetti, Anna Ghazaryan, Paolo Maria Rossini, Maria Maddalena Filippi

Research output: Contribution to journalArticlepeer-review


Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.

Original languageEnglish
Pages (from-to)1552-1558
Number of pages7
JournalJournal of Neurology
Issue number8
Publication statusPublished - 2014


  • Cortical excitability
  • Multiple sclerosis (MS) fatigue
  • Primary somatosensory cortex (S1)
  • Quality of life
  • transcranial direct current stimulation (tDCS)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


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