Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

N.A. Patsopoulos, S.E. Baranzini, A. Santaniello, P. Shoostari, C. Cotsapas, G. Wong, A.H. Beecham, T. James, J. Replogle, I.S. Vlachos, C. McCabe, T.H. Pers, A. Brandes, C. White, B. Keenan, M. Cimpean, P. Winn, I.-P. Panteliadis, A. Robbins, T.F.M. AndlauerO. Zarzycki, B. Dubois, A. Goris, H.B. Søndergaard, F. Sellebjerg, P.S. Sorensen, H. Ullum, L.W. Thørner, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusic, A. Berthele, V. Pongratz, D. Buck, C. Gasperi, C. Graetz, V. Grummel, B. Hemmer, M. Hoshi, B. Knier, T. Korn, C.M. Lill, F. Luessi, M. Mühlau, F. Zipp, E. Dardiotis, C. Agliardi, A. Amoroso, N. Barizzone, M.D. Benedetti, L. Bernardinelli, P. Cavalla, F. Clarelli, G. Comi, D. Cusi, F. Esposito, L. Ferrè, D. Galimberti, C. Guaschino, M.A. Leone, V. Martinelli, L. Moiola, M. Salvetti, M. Sorosina, D. Vecchio, A. Zauli, S. Santoro, N. Mancini, M. Zuccalà, J. Mescheriakova, C. Van Duijn, S.D. Bos, E.G. Celius, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, I.L. Bomfim, D. Gomez-Cabrero, J. Hillert, M. Jagodic, M. Lindén, F. Piehl, I. Jelčić, R. Martin, M. Sospedra, A. Baker, M. Ban, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, P. Molyneux, M. Neville, J. Thorpe, E. Bradshaw, S.J. Caillier, P. Calabresi, B.A.C. Cree, A. Cross, M. Davis, P.W.I. De Bakker, S. Delgado, M. Dembele, K. Edwards, K. Fitzgerald, I.Y. Frohlich, P.-A. Gourraud, J.L. Haines, H. Hakonarson, D. Kimbrough, N. Isobe, I. Konidari, E. Lathi, M.H. Lee, T. Li, D. An, A. Zimmer, L. Madireddy, C.P. Manrique, M. Mitrovic, M. Olah, E. Patrick, M.A. Pericak-Vance, L. Piccio, C. Schaefer, H. Weiner, K. Lage, A. Compston, D. Hafler, H.F. Harbo, S.L. Hauser, G. Stewart, S. D’Alfonso, G. Hadjigeorgiou, B. Taylor, L.F. Barcellos, D. Booth, R. Hintzen, I. Kockum, F. Martinelli-Boneschi, J.L. McCauley, J.R. Oksenberg, A. Oturai, S. Sawcer, A.J. Ivinson, T. Olsson, P.L. De Jager, International Multiple Sclerosis Genetics Consortium, WTCCC2 ANZgene IIBDGC

Research output: Contribution to journal › Article

Original languageEnglish
JournalScience
Volume365
Issue number6460
DOIs
Publication statusPublished - 2019

Cite this

Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., ... ANZgene IIBDGC, WTCCC. (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 365(6460). https://doi.org/10.1126/science.aav7188

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. / Patsopoulos, N.A.; Baranzini, S.E.; Santaniello, A.; Shoostari, P.; Cotsapas, C.; Wong, G.; Beecham, A.H.; James, T.; Replogle, J.; Vlachos, I.S.; McCabe, C.; Pers, T.H.; Brandes, A.; White, C.; Keenan, B.; Cimpean, M.; Winn, P.; Panteliadis, I.-P.; Robbins, A.; Andlauer, T.F.M.; Zarzycki, O.; Dubois, B.; Goris, A.; Søndergaard, H.B.; Sellebjerg, F.; Sorensen, P.S.; Ullum, H.; Thørner, L.W.; Saarela, J.; Cournu-Rebeix, I.; Damotte, V.; Fontaine, B.; Guillot-Noel, L.; Lathrop, M.; Vukusic, S.; Berthele, A.; Pongratz, V.; Buck, D.; Gasperi, C.; Graetz, C.; Grummel, V.; Hemmer, B.; Hoshi, M.; Knier, B.; Korn, T.; Lill, C.M.; Luessi, F.; Mühlau, M.; Zipp, F.; Dardiotis, E.; Agliardi, C.; Amoroso, A.; Barizzone, N.; Benedetti, M.D.; Bernardinelli, L.; Cavalla, P.; Clarelli, F.; Comi, G.; Cusi, D.; Esposito, F.; Ferrè, L.; Galimberti, D.; Guaschino, C.; Leone, M.A.; Martinelli, V.; Moiola, L.; Salvetti, M.; Sorosina, M.; Vecchio, D.; Zauli, A.; Santoro, S.; Mancini, N.; Zuccalà, M.; Mescheriakova, J.; Van Duijn, C.; Bos, S.D.; Celius, E.G.; Spurkland, A.; Comabella, M.; Montalban, X.; Alfredsson, L.; Bomfim, I.L.; Gomez-Cabrero, D.; Hillert, J.; Jagodic, M.; Lindén, M.; Piehl, F.; Jelčić, I.; Martin, R.; Sospedra, M.; Baker, A.; Ban, M.; Hawkins, C.; Hysi, P.; Kalra, S.; Karpe, F.; Khadake, J.; Lachance, G.; Molyneux, P.; Neville, M.; Thorpe, J.; Bradshaw, E.; Caillier, S.J.; Calabresi, P.; Cree, B.A.C.; Cross, A.; Davis, M.; De Bakker, P.W.I.; Delgado, S.; Dembele, M.; Edwards, K.; Fitzgerald, K.; Frohlich, I.Y.; Gourraud, P.-A.; Haines, J.L.; Hakonarson, H.; Kimbrough, D.; Isobe, N.; Konidari, I.; Lathi, E.; Lee, M.H.; Li, T.; An, D.; Zimmer, A.; Madireddy, L.; Manrique, C.P.; Mitrovic, M.; Olah, M.; Patrick, E.; Pericak-Vance, M.A.; Piccio, L.; Schaefer, C.; Weiner, H.; Lage, K.; Compston, A.; Hafler, D.; Harbo, H.F.; Hauser, S.L.; Stewart, G.; D’Alfonso, S.; Hadjigeorgiou, G.; Taylor, B.; Barcellos, L.F.; Booth, D.; Hintzen, R.; Kockum, I.; Martinelli-Boneschi, F.; McCauley, J.L.; Oksenberg, J.R.; Oturai, A.; Sawcer, S.; Ivinson, A.J.; Olsson, T.; De Jager, P.L.; Consortium, International Multiple Sclerosis Genetics; ANZgene IIBDGC, WTCCC2.

In: Science, Vol. 365, No. 6460, 2019.

Research output: Contribution to journal › Article

Patsopoulos, NA, Baranzini, SE, Santaniello, A, Shoostari, P, Cotsapas, C, Wong, G, Beecham, AH, James, T, Replogle, J, Vlachos, IS, McCabe, C, Pers, TH, Brandes, A, White, C, Keenan, B, Cimpean, M, Winn, P, Panteliadis, I-P, Robbins, A, Andlauer, TFM, Zarzycki, O, Dubois, B, Goris, A, Søndergaard, HB, Sellebjerg, F, Sorensen, PS, Ullum, H, Thørner, LW, Saarela, J, Cournu-Rebeix, I, Damotte, V, Fontaine, B, Guillot-Noel, L, Lathrop, M, Vukusic, S, Berthele, A, Pongratz, V, Buck, D, Gasperi, C, Graetz, C, Grummel, V, Hemmer, B, Hoshi, M, Knier, B, Korn, T, Lill, CM, Luessi, F, Mühlau, M, Zipp, F, Dardiotis, E, Agliardi, C, Amoroso, A, Barizzone, N, Benedetti, MD, Bernardinelli, L, Cavalla, P, Clarelli, F, Comi, G, Cusi, D, Esposito, F, Ferrè, L, Galimberti, D, Guaschino, C, Leone, MA, Martinelli, V, Moiola, L, Salvetti, M, Sorosina, M, Vecchio, D, Zauli, A, Santoro, S, Mancini, N, Zuccalà, M, Mescheriakova, J, Van Duijn, C, Bos, SD, Celius, EG, Spurkland, A, Comabella, M, Montalban, X, Alfredsson, L, Bomfim, IL, Gomez-Cabrero, D, Hillert, J, Jagodic, M, Lindén, M, Piehl, F, Jelčić, I, Martin, R, Sospedra, M, Baker, A, Ban, M, Hawkins, C, Hysi, P, Kalra, S, Karpe, F, Khadake, J, Lachance, G, Molyneux, P, Neville, M, Thorpe, J, Bradshaw, E, Caillier, SJ, Calabresi, P, Cree, BAC, Cross, A, Davis, M, De Bakker, PWI, Delgado, S, Dembele, M, Edwards, K, Fitzgerald, K, Frohlich, IY, Gourraud, P-A, Haines, JL, Hakonarson, H, Kimbrough, D, Isobe, N, Konidari, I, Lathi, E, Lee, MH, Li, T, An, D, Zimmer, A, Madireddy, L, Manrique, CP, Mitrovic, M, Olah, M, Patrick, E, Pericak-Vance, MA, Piccio, L, Schaefer, C, Weiner, H, Lage, K, Compston, A, Hafler, D, Harbo, HF, Hauser, SL, Stewart, G, D’Alfonso, S, Hadjigeorgiou, G, Taylor, B, Barcellos, LF, Booth, D, Hintzen, R, Kockum, I, Martinelli-Boneschi, F, McCauley, JL, Oksenberg, JR, Oturai, A, Sawcer, S, Ivinson, AJ, Olsson, T, De Jager, PL, Consortium, IMSG & ANZgene IIBDGC, WTCCC 2019, 'Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility', Science, vol. 365, no. 6460. https://doi.org/10.1126/science.aav7188
Patsopoulos NA, Baranzini SE, Santaniello A, Shoostari P, Cotsapas C, Wong G et al. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019;365(6460). https://doi.org/10.1126/science.aav7188
Patsopoulos, N.A. ; Baranzini, S.E. ; Santaniello, A. ; Shoostari, P. ; Cotsapas, C. ; Wong, G. ; Beecham, A.H. ; James, T. ; Replogle, J. ; Vlachos, I.S. ; McCabe, C. ; Pers, T.H. ; Brandes, A. ; White, C. ; Keenan, B. ; Cimpean, M. ; Winn, P. ; Panteliadis, I.-P. ; Robbins, A. ; Andlauer, T.F.M. ; Zarzycki, O. ; Dubois, B. ; Goris, A. ; Søndergaard, H.B. ; Sellebjerg, F. ; Sorensen, P.S. ; Ullum, H. ; Thørner, L.W. ; Saarela, J. ; Cournu-Rebeix, I. ; Damotte, V. ; Fontaine, B. ; Guillot-Noel, L. ; Lathrop, M. ; Vukusic, S. ; Berthele, A. ; Pongratz, V. ; Buck, D. ; Gasperi, C. ; Graetz, C. ; Grummel, V. ; Hemmer, B. ; Hoshi, M. ; Knier, B. ; Korn, T. ; Lill, C.M. ; Luessi, F. ; Mühlau, M. ; Zipp, F. ; Dardiotis, E. ; Agliardi, C. ; Amoroso, A. ; Barizzone, N. ; Benedetti, M.D. ; Bernardinelli, L. ; Cavalla, P. ; Clarelli, F. ; Comi, G. ; Cusi, D. ; Esposito, F. ; Ferrè, L. ; Galimberti, D. ; Guaschino, C. ; Leone, M.A. ; Martinelli, V. ; Moiola, L. ; Salvetti, M. ; Sorosina, M. ; Vecchio, D. ; Zauli, A. ; Santoro, S. ; Mancini, N. ; Zuccalà, M. ; Mescheriakova, J. ; Van Duijn, C. ; Bos, S.D. ; Celius, E.G. ; Spurkland, A. ; Comabella, M. ; Montalban, X. ; Alfredsson, L. ; Bomfim, I.L. ; Gomez-Cabrero, D. ; Hillert, J. ; Jagodic, M. ; Lindén, M. ; Piehl, F. ; Jelčić, I. ; Martin, R. ; Sospedra, M. ; Baker, A. ; Ban, M. ; Hawkins, C. ; Hysi, P. ; Kalra, S. ; Karpe, F. ; Khadake, J. ; Lachance, G. ; Molyneux, P. ; Neville, M. ; Thorpe, J. ; Bradshaw, E. ; Caillier, S.J. ; Calabresi, P. ; Cree, B.A.C. ; Cross, A. ; Davis, M. ; De Bakker, P.W.I. ; Delgado, S. ; Dembele, M. ; Edwards, K. ; Fitzgerald, K. ; Frohlich, I.Y. ; Gourraud, P.-A. ; Haines, J.L. ; Hakonarson, H. ; Kimbrough, D. ; Isobe, N. ; Konidari, I. ; Lathi, E. ; Lee, M.H. ; Li, T. ; An, D. ; Zimmer, A. ; Madireddy, L. ; Manrique, C.P. ; Mitrovic, M. ; Olah, M. ; Patrick, E. ; Pericak-Vance, M.A. ; Piccio, L. ; Schaefer, C. ; Weiner, H. ; Lage, K. ; Compston, A. ; Hafler, D. ; Harbo, H.F. ; Hauser, S.L. ; Stewart, G. ; D’Alfonso, S. ; Hadjigeorgiou, G. ; Taylor, B. ; Barcellos, L.F. ; Booth, D. ; Hintzen, R. ; Kockum, I. ; Martinelli-Boneschi, F. ; McCauley, J.L. ; Oksenberg, J.R. ; Oturai, A. ; Sawcer, S. ; Ivinson, A.J. ; Olsson, T. ; De Jager, P.L. ; Consortium, International Multiple Sclerosis Genetics ; ANZgene IIBDGC, WTCCC2. / Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. In: Science. 2019 ; Vol. 365, No. 6460.
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title = "Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility",
author = "N.A. Patsopoulos and S.E. Baranzini and A. Santaniello and P. Shoostari and C. Cotsapas and G. Wong and A.H. Beecham and T. James and J. Replogle and I.S. Vlachos and C. McCabe and T.H. Pers and A. Brandes and C. White and B. Keenan and M. Cimpean and P. Winn and I.-P. Panteliadis and A. Robbins and T.F.M. Andlauer and O. Zarzycki and B. Dubois and A. Goris and H.B. S{\o}ndergaard and F. Sellebjerg and P.S. Sorensen and H. Ullum and L.W. Th{\o}rner and J. Saarela and I. Cournu-Rebeix and V. Damotte and B. Fontaine and L. Guillot-Noel and M. Lathrop and S. Vukusic and A. Berthele and V. Pongratz and D. Buck and C. Gasperi and C. Graetz and V. Grummel and B. Hemmer and M. Hoshi and B. Knier and T. Korn and C.M. Lill and F. Luessi and M. M{\"u}hlau and F. Zipp and E. Dardiotis and C. Agliardi and A. Amoroso and N. Barizzone and M.D. Benedetti and L. Bernardinelli and P. Cavalla and F. Clarelli and G. Comi and D. Cusi and F. Esposito and L. Ferr{\`e} and D. Galimberti and C. Guaschino and M.A. Leone and V. Martinelli and L. Moiola and M. Salvetti and M. Sorosina and D. Vecchio and A. Zauli and S. Santoro and N. Mancini and M. Zuccal{\`a} and J. Mescheriakova and {Van Duijn}, C. and S.D. Bos and E.G. Celius and A. Spurkland and M. Comabella and X. Montalban and L. Alfredsson and I.L. Bomfim and D. Gomez-Cabrero and J. Hillert and M. Jagodic and M. Lind{\'e}n and F. Piehl and I. Jelčić and R. Martin and M. Sospedra and A. Baker and M. Ban and C. Hawkins and P. Hysi and S. Kalra and F. Karpe and J. Khadake and G. Lachance and P. Molyneux and M. Neville and J. Thorpe and E. Bradshaw and S.J. Caillier and P. Calabresi and B.A.C. Cree and A. Cross and M. Davis and {De Bakker}, P.W.I. and S. Delgado and M. Dembele and K. Edwards and K. Fitzgerald and I.Y. Frohlich and P.-A. Gourraud and J.L. Haines and H. Hakonarson and D. Kimbrough and N. Isobe and I. Konidari and E. Lathi and M.H. Lee and T. Li and D. An and A. Zimmer and L. Madireddy and C.P. Manrique and M. Mitrovic and M. Olah and E. Patrick and M.A. Pericak-Vance and L. Piccio and C. Schaefer and H. Weiner and K. Lage and A. Compston and D. Hafler and H.F. Harbo and S.L. Hauser and G. Stewart and S. D’Alfonso and G. Hadjigeorgiou and B. Taylor and L.F. Barcellos and D. Booth and R. Hintzen and I. Kockum and F. Martinelli-Boneschi and J.L. McCauley and J.R. Oksenberg and A. Oturai and S. Sawcer and A.J. Ivinson and T. Olsson and {De Jager}, P.L. and Consortium, {International Multiple Sclerosis Genetics} and {ANZgene IIBDGC}, WTCCC2",
note = "Cited By :1 Export Date: 7 October 2019",
year = "2019",
doi = "10.1126/science.aav7188",
language = "English",
volume = "365",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6460",

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TY - JOUR

T1 - Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

AU - Patsopoulos, N.A.

AU - Baranzini, S.E.

AU - Santaniello, A.

AU - Shoostari, P.

AU - Cotsapas, C.

AU - Wong, G.

AU - Beecham, A.H.

AU - James, T.

AU - Replogle, J.

AU - Vlachos, I.S.

AU - McCabe, C.

AU - Pers, T.H.

AU - Brandes, A.

AU - White, C.

AU - Keenan, B.

AU - Cimpean, M.

AU - Winn, P.

AU - Panteliadis, I.-P.

AU - Robbins, A.

AU - Andlauer, T.F.M.

AU - Zarzycki, O.

AU - Dubois, B.

AU - Goris, A.

AU - Søndergaard, H.B.

AU - Sellebjerg, F.

AU - Sorensen, P.S.

AU - Ullum, H.

AU - Thørner, L.W.

AU - Saarela, J.

AU - Cournu-Rebeix, I.

AU - Damotte, V.

AU - Fontaine, B.

AU - Guillot-Noel, L.

AU - Lathrop, M.

AU - Vukusic, S.

AU - Berthele, A.

AU - Pongratz, V.

AU - Buck, D.

AU - Gasperi, C.

AU - Graetz, C.

AU - Grummel, V.

AU - Hemmer, B.

AU - Hoshi, M.

AU - Knier, B.

AU - Korn, T.

AU - Lill, C.M.

AU - Luessi, F.

AU - Mühlau, M.

AU - Zipp, F.

AU - Dardiotis, E.

AU - Agliardi, C.

AU - Amoroso, A.

AU - Barizzone, N.

AU - Benedetti, M.D.

AU - Bernardinelli, L.

AU - Cavalla, P.

AU - Clarelli, F.

AU - Comi, G.

AU - Cusi, D.

AU - Esposito, F.

AU - Ferrè, L.

AU - Galimberti, D.

AU - Guaschino, C.

AU - Leone, M.A.

AU - Martinelli, V.

AU - Moiola, L.

AU - Salvetti, M.

AU - Sorosina, M.

AU - Vecchio, D.

AU - Zauli, A.

AU - Santoro, S.

AU - Mancini, N.

AU - Zuccalà, M.

AU - Mescheriakova, J.

AU - Van Duijn, C.

AU - Bos, S.D.

AU - Celius, E.G.

AU - Spurkland, A.

AU - Comabella, M.

AU - Montalban, X.

AU - Alfredsson, L.

AU - Bomfim, I.L.

AU - Gomez-Cabrero, D.

AU - Hillert, J.

AU - Jagodic, M.

AU - Lindén, M.

AU - Piehl, F.

AU - Jelčić, I.

AU - Martin, R.

AU - Sospedra, M.

AU - Baker, A.

AU - Ban, M.

AU - Hawkins, C.

AU - Hysi, P.

AU - Kalra, S.

AU - Karpe, F.

AU - Khadake, J.

AU - Lachance, G.

AU - Molyneux, P.

AU - Neville, M.

AU - Thorpe, J.

AU - Bradshaw, E.

AU - Caillier, S.J.

AU - Calabresi, P.

AU - Cree, B.A.C.

AU - Cross, A.

AU - Davis, M.

AU - De Bakker, P.W.I.

AU - Delgado, S.

AU - Dembele, M.

AU - Edwards, K.

AU - Fitzgerald, K.

AU - Frohlich, I.Y.

AU - Gourraud, P.-A.

AU - Haines, J.L.

AU - Hakonarson, H.

AU - Kimbrough, D.

AU - Isobe, N.

AU - Konidari, I.

AU - Lathi, E.

AU - Lee, M.H.

AU - Li, T.

AU - An, D.

AU - Zimmer, A.

AU - Madireddy, L.

AU - Manrique, C.P.

AU - Mitrovic, M.

AU - Olah, M.

AU - Patrick, E.

AU - Pericak-Vance, M.A.

AU - Piccio, L.

AU - Schaefer, C.

AU - Weiner, H.

AU - Lage, K.

AU - Compston, A.

AU - Hafler, D.

AU - Harbo, H.F.

AU - Hauser, S.L.

AU - Stewart, G.

AU - D’Alfonso, S.

AU - Hadjigeorgiou, G.

AU - Taylor, B.

AU - Barcellos, L.F.

AU - Booth, D.

AU - Hintzen, R.

AU - Kockum, I.

AU - Martinelli-Boneschi, F.

AU - McCauley, J.L.

AU - Oksenberg, J.R.

AU - Oturai, A.

AU - Sawcer, S.

AU - Ivinson, A.J.

AU - Olsson, T.

AU - De Jager, P.L.

AU - Consortium, International Multiple Sclerosis Genetics

AU - ANZgene IIBDGC, WTCCC2

N1 - Cited By :1 Export Date: 7 October 2019

PY - 2019

Y1 - 2019

U2 - 10.1126/science.aav7188

DO - 10.1126/science.aav7188

M3 - Article

VL - 365

JO - Science

JF - Science

SN - 0036-8075

IS - 6460

ER -

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