Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies

Mathias Mäurer, Giancarlo Comi, Mark S. Freedman, Ludwig Kappos, Tomas P. Olsson, Jerry S. Wolinsky, Aaron E. Miller, Catherine Dive-Pouletty, Sylvie Bozzi, Paul W. O'Connor

Research output: Contribution to journalArticlepeer-review

Abstract

Background Two pivotal phase 3 teriflunomide studies provided data on relapses, fatigue, and health-related quality of life (HRQoL) in patients with relapsing forms of multiple sclerosis (MS). Objectives Using pooled data from the TEMSO (NCT00134563) and TOWER (NCT00751881) studies, we investigated the association between relapse severity, and changes from baseline to Week 108 in fatigue and HRQoL outcomes. Methods Four definitions of relapse severity were applied in this analysis: sequelae post-relapse; relapse leading to hospitalization; relapse requiring intravenous corticosteroids; and intense relapse. We assessed the association between relapse severity and changes in Fatigue Impact Scale score (n=959), physical and mental health component summary scores from the Short Form (SF)-36 questionnaire (n=904), and SF-6D utility index scores (n=820). Results Irrespective of the definition of relapse severity applied, in patients experiencing severe relapse(s), fatigue was increased and HRQoL was decreased; these changes were statistically significant (p

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalMultiple Sclerosis and Related Disorders
Volume7
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Fatigue
  • FIS
  • Multiple sclerosis
  • Quality of life
  • Relapse
  • Sequelae
  • SF-36
  • Teriflunomide

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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