Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies

Mathias Mäurer; Giancarlo Comi; Mark S. Freedman; Ludwig Kappos; Tomas P. Olsson; Jerry S. Wolinsky; Aaron E. Miller; Catherine Dive-Pouletty; Sylvie Bozzi; Paul W. O'Connor

doi:10.1016/j.msard.2016.02.012

Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies

Mathias Mäurer, Giancarlo Comi, Mark S. Freedman, Ludwig Kappos, Tomas P. Olsson, Jerry S. Wolinsky, Aaron E. Miller, Catherine Dive-Pouletty, Sylvie Bozzi, Paul W. O'Connor

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background Two pivotal phase 3 teriflunomide studies provided data on relapses, fatigue, and health-related quality of life (HRQoL) in patients with relapsing forms of multiple sclerosis (MS). Objectives Using pooled data from the TEMSO (NCT00134563) and TOWER (NCT00751881) studies, we investigated the association between relapse severity, and changes from baseline to Week 108 in fatigue and HRQoL outcomes. Methods Four definitions of relapse severity were applied in this analysis: sequelae post-relapse; relapse leading to hospitalization; relapse requiring intravenous corticosteroids; and intense relapse. We assessed the association between relapse severity and changes in Fatigue Impact Scale score (n=959), physical and mental health component summary scores from the Short Form (SF)-36 questionnaire (n=904), and SF-6D utility index scores (n=820). Results Irrespective of the definition of relapse severity applied, in patients experiencing severe relapse(s), fatigue was increased and HRQoL was decreased; these changes were statistically significant (p

Original language	English
Pages (from-to)	33-40
Number of pages	8
Journal	Multiple Sclerosis and Related Disorders
Volume	7
DOIs	https://doi.org/10.1016/j.msard.2016.02.012
Publication status	Published - May 1 2016

Keywords

Fatigue
FIS
Multiple sclerosis
Quality of life
Relapse
Sequelae
SF-36
Teriflunomide

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Mäurer, M., Comi, G., Freedman, M. S., Kappos, L., Olsson, T. P., Wolinsky, J. S., Miller, A. E., Dive-Pouletty, C., Bozzi, S., & O'Connor, P. W. (2016). Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies. Multiple Sclerosis and Related Disorders, 7, 33-40. https://doi.org/10.1016/j.msard.2016.02.012

Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies. / Mäurer, Mathias; Comi, Giancarlo; Freedman, Mark S.; Kappos, Ludwig; Olsson, Tomas P.; Wolinsky, Jerry S.; Miller, Aaron E.; Dive-Pouletty, Catherine; Bozzi, Sylvie; O'Connor, Paul W.

In: Multiple Sclerosis and Related Disorders, Vol. 7, 01.05.2016, p. 33-40.

Research output: Contribution to journal › Article › peer-review

Mäurer, M, Comi, G, Freedman, MS, Kappos, L, Olsson, TP, Wolinsky, JS, Miller, AE, Dive-Pouletty, C, Bozzi, S & O'Connor, PW 2016, 'Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies', Multiple Sclerosis and Related Disorders, vol. 7, pp. 33-40. https://doi.org/10.1016/j.msard.2016.02.012

Mäurer, Mathias ; Comi, Giancarlo ; Freedman, Mark S. ; Kappos, Ludwig ; Olsson, Tomas P. ; Wolinsky, Jerry S. ; Miller, Aaron E. ; Dive-Pouletty, Catherine ; Bozzi, Sylvie ; O'Connor, Paul W. / Multiple sclerosis relapses are associated with increased fatigue and reduced health-related quality of life - A post hoc analysis of the TEMSO and TOWER studies. In: Multiple Sclerosis and Related Disorders. 2016 ; Vol. 7. pp. 33-40.

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abstract = "Background Two pivotal phase 3 teriflunomide studies provided data on relapses, fatigue, and health-related quality of life (HRQoL) in patients with relapsing forms of multiple sclerosis (MS). Objectives Using pooled data from the TEMSO (NCT00134563) and TOWER (NCT00751881) studies, we investigated the association between relapse severity, and changes from baseline to Week 108 in fatigue and HRQoL outcomes. Methods Four definitions of relapse severity were applied in this analysis: sequelae post-relapse; relapse leading to hospitalization; relapse requiring intravenous corticosteroids; and intense relapse. We assessed the association between relapse severity and changes in Fatigue Impact Scale score (n=959), physical and mental health component summary scores from the Short Form (SF)-36 questionnaire (n=904), and SF-6D utility index scores (n=820). Results Irrespective of the definition of relapse severity applied, in patients experiencing severe relapse(s), fatigue was increased and HRQoL was decreased; these changes were statistically significant (p",

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AU - Freedman, Mark S.

AU - Kappos, Ludwig

AU - Olsson, Tomas P.

AU - Wolinsky, Jerry S.

AU - Miller, Aaron E.

AU - Dive-Pouletty, Catherine

AU - Bozzi, Sylvie

AU - O'Connor, Paul W.

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N2 - Background Two pivotal phase 3 teriflunomide studies provided data on relapses, fatigue, and health-related quality of life (HRQoL) in patients with relapsing forms of multiple sclerosis (MS). Objectives Using pooled data from the TEMSO (NCT00134563) and TOWER (NCT00751881) studies, we investigated the association between relapse severity, and changes from baseline to Week 108 in fatigue and HRQoL outcomes. Methods Four definitions of relapse severity were applied in this analysis: sequelae post-relapse; relapse leading to hospitalization; relapse requiring intravenous corticosteroids; and intense relapse. We assessed the association between relapse severity and changes in Fatigue Impact Scale score (n=959), physical and mental health component summary scores from the Short Form (SF)-36 questionnaire (n=904), and SF-6D utility index scores (n=820). Results Irrespective of the definition of relapse severity applied, in patients experiencing severe relapse(s), fatigue was increased and HRQoL was decreased; these changes were statistically significant (p

AB - Background Two pivotal phase 3 teriflunomide studies provided data on relapses, fatigue, and health-related quality of life (HRQoL) in patients with relapsing forms of multiple sclerosis (MS). Objectives Using pooled data from the TEMSO (NCT00134563) and TOWER (NCT00751881) studies, we investigated the association between relapse severity, and changes from baseline to Week 108 in fatigue and HRQoL outcomes. Methods Four definitions of relapse severity were applied in this analysis: sequelae post-relapse; relapse leading to hospitalization; relapse requiring intravenous corticosteroids; and intense relapse. We assessed the association between relapse severity and changes in Fatigue Impact Scale score (n=959), physical and mental health component summary scores from the Short Form (SF)-36 questionnaire (n=904), and SF-6D utility index scores (n=820). Results Irrespective of the definition of relapse severity applied, in patients experiencing severe relapse(s), fatigue was increased and HRQoL was decreased; these changes were statistically significant (p

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