Multiple sclerosis severity score: Using disability and disease duration to rate disease severity

R. H S R Roxburgh, S. R. Seaman, T. Masterman, A. E. Hensiek, S. J. Sawcer, S. Vukusic, I. Achiti, C. Confavreux, M. Coustans, E. Le Page, G. Edan, G. V. McDonnell, S. Hawkins, M. Trojano, M. Liguori, E. Cocco, M. G. Marrosu, F. Tesser, M. A. Leone, A. WeberF. Zipp, B. Miterski, J. T. Epplen, A. Oturai, P. Soelberg Sørensen, E. G. Celius, N. Téllez Lara, X. Montalban, P. Villoslada, A. M. Silva, M. Marta, I. Leite, B. Dubois, J. Rubio, H. Butzkueven, T. Kilpatrick, M. P. Mycko, K. W. Selmaj, M. E. Rio, M. Sá, G. Salemi, G. Savettieri, J. Hillert, D. A S Compston

Research output: Contribution to journalArticle

Abstract

Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

Original languageEnglish
Pages (from-to)1144-1151
Number of pages8
JournalNeurology
Volume64
Issue number7
Publication statusPublished - Apr 12 2005

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Multiple Sclerosis
Disease Progression
Databases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Roxburgh, R. H. S. R., Seaman, S. R., Masterman, T., Hensiek, A. E., Sawcer, S. J., Vukusic, S., ... Compston, D. A. S. (2005). Multiple sclerosis severity score: Using disability and disease duration to rate disease severity. Neurology, 64(7), 1144-1151.

Multiple sclerosis severity score : Using disability and disease duration to rate disease severity. / Roxburgh, R. H S R; Seaman, S. R.; Masterman, T.; Hensiek, A. E.; Sawcer, S. J.; Vukusic, S.; Achiti, I.; Confavreux, C.; Coustans, M.; Le Page, E.; Edan, G.; McDonnell, G. V.; Hawkins, S.; Trojano, M.; Liguori, M.; Cocco, E.; Marrosu, M. G.; Tesser, F.; Leone, M. A.; Weber, A.; Zipp, F.; Miterski, B.; Epplen, J. T.; Oturai, A.; Sørensen, P. Soelberg; Celius, E. G.; Lara, N. Téllez; Montalban, X.; Villoslada, P.; Silva, A. M.; Marta, M.; Leite, I.; Dubois, B.; Rubio, J.; Butzkueven, H.; Kilpatrick, T.; Mycko, M. P.; Selmaj, K. W.; Rio, M. E.; Sá, M.; Salemi, G.; Savettieri, G.; Hillert, J.; Compston, D. A S.

In: Neurology, Vol. 64, No. 7, 12.04.2005, p. 1144-1151.

Research output: Contribution to journalArticle

Roxburgh, RHSR, Seaman, SR, Masterman, T, Hensiek, AE, Sawcer, SJ, Vukusic, S, Achiti, I, Confavreux, C, Coustans, M, Le Page, E, Edan, G, McDonnell, GV, Hawkins, S, Trojano, M, Liguori, M, Cocco, E, Marrosu, MG, Tesser, F, Leone, MA, Weber, A, Zipp, F, Miterski, B, Epplen, JT, Oturai, A, Sørensen, PS, Celius, EG, Lara, NT, Montalban, X, Villoslada, P, Silva, AM, Marta, M, Leite, I, Dubois, B, Rubio, J, Butzkueven, H, Kilpatrick, T, Mycko, MP, Selmaj, KW, Rio, ME, Sá, M, Salemi, G, Savettieri, G, Hillert, J & Compston, DAS 2005, 'Multiple sclerosis severity score: Using disability and disease duration to rate disease severity', Neurology, vol. 64, no. 7, pp. 1144-1151.
Roxburgh RHSR, Seaman SR, Masterman T, Hensiek AE, Sawcer SJ, Vukusic S et al. Multiple sclerosis severity score: Using disability and disease duration to rate disease severity. Neurology. 2005 Apr 12;64(7):1144-1151.
Roxburgh, R. H S R ; Seaman, S. R. ; Masterman, T. ; Hensiek, A. E. ; Sawcer, S. J. ; Vukusic, S. ; Achiti, I. ; Confavreux, C. ; Coustans, M. ; Le Page, E. ; Edan, G. ; McDonnell, G. V. ; Hawkins, S. ; Trojano, M. ; Liguori, M. ; Cocco, E. ; Marrosu, M. G. ; Tesser, F. ; Leone, M. A. ; Weber, A. ; Zipp, F. ; Miterski, B. ; Epplen, J. T. ; Oturai, A. ; Sørensen, P. Soelberg ; Celius, E. G. ; Lara, N. Téllez ; Montalban, X. ; Villoslada, P. ; Silva, A. M. ; Marta, M. ; Leite, I. ; Dubois, B. ; Rubio, J. ; Butzkueven, H. ; Kilpatrick, T. ; Mycko, M. P. ; Selmaj, K. W. ; Rio, M. E. ; Sá, M. ; Salemi, G. ; Savettieri, G. ; Hillert, J. ; Compston, D. A S. / Multiple sclerosis severity score : Using disability and disease duration to rate disease severity. In: Neurology. 2005 ; Vol. 64, No. 7. pp. 1144-1151.
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abstract = "Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.",
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T2 - Using disability and disease duration to rate disease severity

AU - Roxburgh, R. H S R

AU - Seaman, S. R.

AU - Masterman, T.

AU - Hensiek, A. E.

AU - Sawcer, S. J.

AU - Vukusic, S.

AU - Achiti, I.

AU - Confavreux, C.

AU - Coustans, M.

AU - Le Page, E.

AU - Edan, G.

AU - McDonnell, G. V.

AU - Hawkins, S.

AU - Trojano, M.

AU - Liguori, M.

AU - Cocco, E.

AU - Marrosu, M. G.

AU - Tesser, F.

AU - Leone, M. A.

AU - Weber, A.

AU - Zipp, F.

AU - Miterski, B.

AU - Epplen, J. T.

AU - Oturai, A.

AU - Sørensen, P. Soelberg

AU - Celius, E. G.

AU - Lara, N. Téllez

AU - Montalban, X.

AU - Villoslada, P.

AU - Silva, A. M.

AU - Marta, M.

AU - Leite, I.

AU - Dubois, B.

AU - Rubio, J.

AU - Butzkueven, H.

AU - Kilpatrick, T.

AU - Mycko, M. P.

AU - Selmaj, K. W.

AU - Rio, M. E.

AU - Sá, M.

AU - Salemi, G.

AU - Savettieri, G.

AU - Hillert, J.

AU - Compston, D. A S

PY - 2005/4/12

Y1 - 2005/4/12

N2 - Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

AB - Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

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