Multiple sensitivities to transition metals: The nickel palladium reactions

B. Santucci, C. Cannistraci, A. Cristaudo, M. Picardo

Research output: Contribution to journalArticlepeer-review


Patch test data of 1000 consecutive patients sensitive to at least 1 substance of our standard series showed that transition metals gave associated reactions amongst themselves more frequently than they did with the remaining substances. The responses to transition metals were largely variable and seemed dependent not only upon the associated exposure to different metals or the concomitant responses of the T cell clones, as reported by others, but also upon the chemical properties of the metals and the consequent interactions inside the skin. Concomitant reactions to nickel sulfate and palladium chloride were the most frequently found associated positivities and occurred in a minority of nickel-sulfate-sensitive subjects. In 43 out of 45 of these subjects, patch tests to mixed solutions containing nickel sulfate, plus sulfates of magnesium, zinc, and manganese at higher doses, were not able to reduce the nickel sulfate reactions. This behaviour contrasted with that found in the majority of subjects sensitive only to nickel sulfate. These findings seem to demonstrate that, whilst in subjects with positive reactions to nickel sulfate alone antigen formation involves biomolecules containing ions, in those with concomitant reactions to palladium chloride, other structures are involved.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalContact Dermatitis
Issue number5
Publication statusPublished - 1996


  • Chemical basis
  • Complexes
  • Concomitant hypersensitivities
  • Contact dermatitis
  • Nickel
  • Palladium
  • Transition metals

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology


Dive into the research topics of 'Multiple sensitivities to transition metals: The nickel palladium reactions'. Together they form a unique fingerprint.

Cite this