Multiple spinal meningiomas after tamoxifen therapy: A case report

G. B. Colazza, G. Di Gennaro, P. P. Quarato, C. Colonnese, A. Mascia, M. Manfredi

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We describe a rare case of multiple spinal meningiomas and evaluate the possible relationship with tamoxifen treatment. We observed a 74-year-old woman who showed a spastic paraparesis gradually developed in the last year. The patient underwent left mastectomy for a breast cancer ten years earlier and was treated with tamoxifen for four years after surgical intervention. Magnetic resonance imaging revealed three spinal meningiomas at C6-C7, D6-D7 and D9 levels. Taking in account the tumor-inducing properties of tamoxifen and the extreme rarity of multiple spinal meningiomas, we suggest that tamoxifen may be the cause play a role in the genesis of the spinal meningiomatosis in the observed patient. Therefore, we propose the long-term clinical and neurological surveillance of patients who assumed tamoxifen, even for a short time, in order to survey the possible appearance of secondary tumours.

Original languageEnglish
Pages (from-to)37-39
Number of pages3
JournalNeurological Sciences
Issue number1
Publication statusPublished - Apr 2003


  • MRI
  • Spinal multiple meningiomas
  • Tamoxifen

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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