Abstract
GISTs originating multifocally at different GI sites, in patients lacking familial syndromes, could be interpreted as recurrent/metastatic disease. MiR-221/222 have recently been identified as regulators of KIT expression in GISTs. We report the first case of synchronous GISTs in the stomach and duodenum concomitant with an ampullary adenocarcinoma. Different CD117 expression patterns could be related to different KIT mutational status in the two lesions: gastric GIST showed a dot-like pattern and lacked KIT mutations; duodenal GIST had a strong membranous expression pattern, likely due to KIT exon 9 duplication, which is associated with lower response to imatinib. MiR-221/222 were downregulated in GISTs as compared with normal tissue (p
Original language | English |
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Pages (from-to) | 392-396 |
Number of pages | 5 |
Journal | Pathology Research and Practice |
Volume | 210 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Adenocarcinoma
- GISTs
- MiR-221/222
- Mutation
- Polyclonality
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology
- Medicine(all)