Multiple synchronous colorectal carcinomas: A ploidy study by image analysis

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Abstract

Cytometry could represent an ancillary technique to morphology in order to understand whether multiple synchronous colorectal carcinomas arose independently. Twenty-eight multiple synchronous tumours, assessed by means of a computerized image analysts system for DNA ploidy, were categorized as diploid (4) or not diploid (24). The ploidy classes were: DNA-diploid, DNA-tetraploid, and DNA-aneuploid. The DNA Index (DI) ranged from 0.90 to 2.66. The overall concordance rate for ploidy and DI class with synchronous tumours was 69% and 31%, respectively. The high concordance rate in ploidic categories suggests the metastatic origin of our multiple synchronous tumours. Moreover, they showed site, Dukes' classification, degree of differentiation, percentage of ploidy class, and DI distribution comparable to the single colorectal carcinomas. In conclusion, image analysis is a reliable technique to determine the independent clonality or the common origin of multiple colorectal tumours when the evaluation based on the simple histopathological criteria is not satisfactory.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalAnticancer Research
Volume18
Issue number1 A
Publication statusPublished - Jan 1998

Keywords

  • Colon cancer
  • Cytometry
  • Ploidy
  • Synchronous cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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