Multiple-target drugs: Inhibitors of heat shock protein 90 and of histone deacetylase

Research output: Contribution to journalArticlepeer-review

Abstract

In spite of the improvement of conventional medical therapy for cancer treatment, the impact on cancer related mortality in the last ten years has been modest especially for advanced disease in adults. On the other hand, understanding of molecular events underlining tumor development lead to the definition of new molecular targets for novel anti-tumor therapeutical approaches. On this regard, several biotechnology products selected by academic as well as industrial research are currently in clinical trials. Epigenetics as well as post-translational modifications of proteins are emerging as novel attractive targets for anticancer therapy. In addition, the heterogeneity of tumor cells within a selected neoplastic lesions as well as the redundancy of proliferative and survival pathways present in cancer cells favor the development of single drugs that are able to affect multiple pathways. Inhibitors of heat shock protein 90 and of histone deacetylase are two novel classes of multi-target agents that entered recently in clinical studies. This review will focus on the most important issues in the development of both these classes of agents.

Original languageEnglish
Pages (from-to)337-351
Number of pages15
JournalCurrent Drug Targets
Volume6
Issue number3
DOIs
Publication statusPublished - May 2005

Keywords

  • Epigenetics
  • ErbB
  • Heat shock protein 90
  • Heat shock protein 90 inhibitors
  • Histone deacetylase
  • Histone deacetylase inhibitors
  • Multi-chaperone
  • Multi-targets drugs

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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