Multiple viral infections in primary effusion lymphoma

a model of viral cooperation in lymphomagenesis

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Introduction: Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis. Areas covered: In this review, the authors highlight clinical, pathologic, genetic and proteomic features of PEL, in the context of viral cooperation in PEL lymphomagenesis. Expert commentary: Tumour cells are characterized by the overexpression of genes that are involved in inflammation and invasion. Coherently, PEL secretomes are enriched in proteins probably responsible for the particular tropism (cell adhesion and migration) of PEL cells. The development of PEL in HIV+ patients is multifactorial and involves a complex interplay among co-infection with oncogenic viruses (EBV and KSHV), inflammatory factors, and environmental conditions.

Original languageEnglish
Pages (from-to)505-514
Number of pages10
JournalExpert Review of Hematology
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 3 2017

Fingerprint

Primary Effusion Lymphoma
Virus Diseases
Human Herpesvirus 8
Human Herpesvirus 4
Coinfection
Herpesviridae Infections
Oncogenic Viruses
Epstein-Barr Virus Infections
Tropism
Pericardial Effusion
Ascitic Fluid
Pleural Effusion
Cell Adhesion
Proteomics
HIV Infections
Cell Movement
Neoplasms
B-Lymphocytes
HIV
Inflammation

Keywords

  • EBV
  • HIV-associated lymphomas
  • KSHV
  • large cell lymphomas
  • lymphomagenesis
  • Primary effusion lymphoma
  • viral cooperation

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Multiple viral infections in primary effusion lymphoma: a model of viral cooperation in lymphomagenesis",
abstract = "Introduction: Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis. Areas covered: In this review, the authors highlight clinical, pathologic, genetic and proteomic features of PEL, in the context of viral cooperation in PEL lymphomagenesis. Expert commentary: Tumour cells are characterized by the overexpression of genes that are involved in inflammation and invasion. Coherently, PEL secretomes are enriched in proteins probably responsible for the particular tropism (cell adhesion and migration) of PEL cells. The development of PEL in HIV+ patients is multifactorial and involves a complex interplay among co-infection with oncogenic viruses (EBV and KSHV), inflammatory factors, and environmental conditions.",
keywords = "EBV, HIV-associated lymphomas, KSHV, large cell lymphomas, lymphomagenesis, Primary effusion lymphoma, viral cooperation",
author = "Annunziata Gloghini and Volpi, {Chiara C.} and Gualeni, {Ambra V.} and Riccardo Dolcetti and Italia Bongarzone and {De Paoli}, Paolo and Antonino Carbone",
year = "2017",
month = "6",
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doi = "10.1080/17474086.2017.1326815",
language = "English",
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TY - JOUR

T1 - Multiple viral infections in primary effusion lymphoma

T2 - a model of viral cooperation in lymphomagenesis

AU - Gloghini, Annunziata

AU - Volpi, Chiara C.

AU - Gualeni, Ambra V.

AU - Dolcetti, Riccardo

AU - Bongarzone, Italia

AU - De Paoli, Paolo

AU - Carbone, Antonino

PY - 2017/6/3

Y1 - 2017/6/3

N2 - Introduction: Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis. Areas covered: In this review, the authors highlight clinical, pathologic, genetic and proteomic features of PEL, in the context of viral cooperation in PEL lymphomagenesis. Expert commentary: Tumour cells are characterized by the overexpression of genes that are involved in inflammation and invasion. Coherently, PEL secretomes are enriched in proteins probably responsible for the particular tropism (cell adhesion and migration) of PEL cells. The development of PEL in HIV+ patients is multifactorial and involves a complex interplay among co-infection with oncogenic viruses (EBV and KSHV), inflammatory factors, and environmental conditions.

AB - Introduction: Primary effusion lymphoma (PEL) is a rare B-cell lymphoid neoplasm mainly associated with HIV infection, presenting as pleural, peritoneal, and pericardial effusions. A defining property of PEL is its consistent association with Kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection. On these grounds, a review of the literature related to viral cooperation and lymphomagenesis can help to understand the complex interplay between KSHV and EBV in PEL pathogenesis. Areas covered: In this review, the authors highlight clinical, pathologic, genetic and proteomic features of PEL, in the context of viral cooperation in PEL lymphomagenesis. Expert commentary: Tumour cells are characterized by the overexpression of genes that are involved in inflammation and invasion. Coherently, PEL secretomes are enriched in proteins probably responsible for the particular tropism (cell adhesion and migration) of PEL cells. The development of PEL in HIV+ patients is multifactorial and involves a complex interplay among co-infection with oncogenic viruses (EBV and KSHV), inflammatory factors, and environmental conditions.

KW - EBV

KW - HIV-associated lymphomas

KW - KSHV

KW - large cell lymphomas

KW - lymphomagenesis

KW - Primary effusion lymphoma

KW - viral cooperation

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