Multiple VLA antigens on a subset of melanoma clones

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Abstract

A panel of 19 melanoma clones was characterized by fluorescence activated cell sorter analysis for the expression of distinct integrin receptors in the very late activation antibody subfamily. A group of five melanoma clones (2/4, 2/14, 2/17, 2/51, and 2/60) was identified that shared coordinate expression of multiple VLA antigens. These same clones were more susceptible, in terms of lytic units, to cell-mediated lysis and also expressed the lower melanin content per cell in the panel. The data suggest that in a heterogenous neoplastic population, distinct features such as susceptibility to cell-mediated lysis and expression of receptors for extracellular components are variables preferentially associated with cells in an early stage of differentiation.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalHuman Immunology
Volume28
Issue number2
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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