Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vive delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vive into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy.
|Number of pages||5|
|Publication status||Published - Sep 1997|
- Gene therapy
- Retrovital vectors
ASJC Scopus subject areas