Multipoint pacing improves peripheral hemodynamic response: Noninvasive assessment using radial artery tonometry

Giuseppe Ciconte, Žarko Ćalović, Gabriele Vicedomini, Amarild Cuko, Luke C. McSpadden, Chunlan Jiang, Kyungmoo Ryu, Igor Caporaso, Robert Stutz, Dean Winter, Massimo Saviano, Raffaele Vitale, Manuel Conti, Vincenzo Santinelli, Carlo Pappone

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], Abbott, Sylmar, CA, USA) improves the response rate to cardiac resynchronization therapy (CRT). We evaluated the feasibility of noninvasive radial artery tonometry (RAT) to characterize arterial pressure morphology changes (pre-ejection period [PEP] and ejection duration [ED]) between conventional CRT and MPP pacing interventions. Methods: Patients with a MPP-enabled CRT device (Quadra Assura MP™, Abbott) underwent noninvasive RAT assessment (SphygmoCor CVMS, AtCor Medical Inc., Itasca, IL, USA) at 3–6 months after implantation. A pacing protocol was performed in a randomized order including one optimized conventional biventricular CRT (CONV) configuration using the distal electrode and five MPP configurations. The PEP, ED, and PEP/ED ratio were determined for each intervention from the RAT pressure waveform and electrocardiogram. Results: Pressure waveforms were successfully recorded in 19 patients (89% male, QRS 147 ± 16 ms, 63% ischemic). In 17/19 (89%) patients, at least one MPP intervention resulted in improved PEP, ED, and PEP/ED compared to CONV. The MPP intervention with greatest separation of LV cathodes and minimum intra-LV delay significantly improved PEP (mean PEP –15 ± 33% vs –8 ± 32% [CONV], P = 0.04) and ED (mean ED +8 ± 8% [MPP] vs +4 ± 7% [CONV], P = 0.02), and PEP/ED (–0.07 ± 0.14 [MPP] vs –0.04 ± 0.13 [CONV], P = 0.02) compared with CONV. Conclusions: Noninvasive RAT efficiently characterizes changes in PEP and ED between CONV and MPP interventions. MPP configurations using the widest separation among LV cathodes and minimum intra-LV delay may significantly improve RAT-derived parameters as compared to conventional CRT.

Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalPACE - Pacing and Clinical Electrophysiology
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

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Radial Artery
Manometry
Cardiac Resynchronization Therapy
Hemodynamics
Electrodes
Cardiac Resynchronization Therapy Devices
Pressure
Arterial Pressure
Electrocardiography

Keywords

  • cardiac resynchronization therapy
  • heart failure
  • multipoint pacing
  • radial artery tonometry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Multipoint pacing improves peripheral hemodynamic response : Noninvasive assessment using radial artery tonometry. / Ciconte, Giuseppe; Ćalović, Žarko; Vicedomini, Gabriele; Cuko, Amarild; McSpadden, Luke C.; Jiang, Chunlan; Ryu, Kyungmoo; Caporaso, Igor; Stutz, Robert; Winter, Dean; Saviano, Massimo; Vitale, Raffaele; Conti, Manuel; Santinelli, Vincenzo; Pappone, Carlo.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 41, No. 2, 01.02.2018, p. 106-113.

Research output: Contribution to journalArticle

Ciconte, G, Ćalović, Ž, Vicedomini, G, Cuko, A, McSpadden, LC, Jiang, C, Ryu, K, Caporaso, I, Stutz, R, Winter, D, Saviano, M, Vitale, R, Conti, M, Santinelli, V & Pappone, C 2018, 'Multipoint pacing improves peripheral hemodynamic response: Noninvasive assessment using radial artery tonometry', PACE - Pacing and Clinical Electrophysiology, vol. 41, no. 2, pp. 106-113. https://doi.org/10.1111/pace.13254
Ciconte, Giuseppe ; Ćalović, Žarko ; Vicedomini, Gabriele ; Cuko, Amarild ; McSpadden, Luke C. ; Jiang, Chunlan ; Ryu, Kyungmoo ; Caporaso, Igor ; Stutz, Robert ; Winter, Dean ; Saviano, Massimo ; Vitale, Raffaele ; Conti, Manuel ; Santinelli, Vincenzo ; Pappone, Carlo. / Multipoint pacing improves peripheral hemodynamic response : Noninvasive assessment using radial artery tonometry. In: PACE - Pacing and Clinical Electrophysiology. 2018 ; Vol. 41, No. 2. pp. 106-113.
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abstract = "Background: Multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], Abbott, Sylmar, CA, USA) improves the response rate to cardiac resynchronization therapy (CRT). We evaluated the feasibility of noninvasive radial artery tonometry (RAT) to characterize arterial pressure morphology changes (pre-ejection period [PEP] and ejection duration [ED]) between conventional CRT and MPP pacing interventions. Methods: Patients with a MPP-enabled CRT device (Quadra Assura MP™, Abbott) underwent noninvasive RAT assessment (SphygmoCor CVMS, AtCor Medical Inc., Itasca, IL, USA) at 3–6 months after implantation. A pacing protocol was performed in a randomized order including one optimized conventional biventricular CRT (CONV) configuration using the distal electrode and five MPP configurations. The PEP, ED, and PEP/ED ratio were determined for each intervention from the RAT pressure waveform and electrocardiogram. Results: Pressure waveforms were successfully recorded in 19 patients (89{\%} male, QRS 147 ± 16 ms, 63{\%} ischemic). In 17/19 (89{\%}) patients, at least one MPP intervention resulted in improved PEP, ED, and PEP/ED compared to CONV. The MPP intervention with greatest separation of LV cathodes and minimum intra-LV delay significantly improved PEP (mean PEP –15 ± 33{\%} vs –8 ± 32{\%} [CONV], P = 0.04) and ED (mean ED +8 ± 8{\%} [MPP] vs +4 ± 7{\%} [CONV], P = 0.02), and PEP/ED (–0.07 ± 0.14 [MPP] vs –0.04 ± 0.13 [CONV], P = 0.02) compared with CONV. Conclusions: Noninvasive RAT efficiently characterizes changes in PEP and ED between CONV and MPP interventions. MPP configurations using the widest separation among LV cathodes and minimum intra-LV delay may significantly improve RAT-derived parameters as compared to conventional CRT.",
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T2 - Noninvasive assessment using radial artery tonometry

AU - Ciconte, Giuseppe

AU - Ćalović, Žarko

AU - Vicedomini, Gabriele

AU - Cuko, Amarild

AU - McSpadden, Luke C.

AU - Jiang, Chunlan

AU - Ryu, Kyungmoo

AU - Caporaso, Igor

AU - Stutz, Robert

AU - Winter, Dean

AU - Saviano, Massimo

AU - Vitale, Raffaele

AU - Conti, Manuel

AU - Santinelli, Vincenzo

AU - Pappone, Carlo

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: Multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], Abbott, Sylmar, CA, USA) improves the response rate to cardiac resynchronization therapy (CRT). We evaluated the feasibility of noninvasive radial artery tonometry (RAT) to characterize arterial pressure morphology changes (pre-ejection period [PEP] and ejection duration [ED]) between conventional CRT and MPP pacing interventions. Methods: Patients with a MPP-enabled CRT device (Quadra Assura MP™, Abbott) underwent noninvasive RAT assessment (SphygmoCor CVMS, AtCor Medical Inc., Itasca, IL, USA) at 3–6 months after implantation. A pacing protocol was performed in a randomized order including one optimized conventional biventricular CRT (CONV) configuration using the distal electrode and five MPP configurations. The PEP, ED, and PEP/ED ratio were determined for each intervention from the RAT pressure waveform and electrocardiogram. Results: Pressure waveforms were successfully recorded in 19 patients (89% male, QRS 147 ± 16 ms, 63% ischemic). In 17/19 (89%) patients, at least one MPP intervention resulted in improved PEP, ED, and PEP/ED compared to CONV. The MPP intervention with greatest separation of LV cathodes and minimum intra-LV delay significantly improved PEP (mean PEP –15 ± 33% vs –8 ± 32% [CONV], P = 0.04) and ED (mean ED +8 ± 8% [MPP] vs +4 ± 7% [CONV], P = 0.02), and PEP/ED (–0.07 ± 0.14 [MPP] vs –0.04 ± 0.13 [CONV], P = 0.02) compared with CONV. Conclusions: Noninvasive RAT efficiently characterizes changes in PEP and ED between CONV and MPP interventions. MPP configurations using the widest separation among LV cathodes and minimum intra-LV delay may significantly improve RAT-derived parameters as compared to conventional CRT.

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KW - cardiac resynchronization therapy

KW - heart failure

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