Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents

Angela Gritti, Luca Bonfanti, Fiona Doetsch, Isabelle Caille, Arturo Alvarez-Buylla, Daniel A. Lim, Rossella Galli, J. M G Verdugo, Daniel G. Herrera, Angelo L. Vescovi

Research output: Contribution to journalArticle

333 Citations (Scopus)

Abstract

The lateral walls of the forebrain lateral ventricles are the richest source of stem cells in the adult mammalian brain. These stem cells give rise to new olfactory neurons that are renewed throughout life. The neurons originate in the subventricular zone (SVZ), migrate within the rostral extension (RE) of the SVZ along the rostral migratory stream (RMS) within tube-like structures formed of glial cells, to eventually reach the olfactory bulb (OB). We demonstrate that, contrary to the current view, multipotential (neuronal-astroglial-oligodendroglial) precursors with stem cell features can be isolated not only from the SVZ but also from the entire RE, including the distal portion within the OB. Specifically, these stem cells do not derive from the migratory neuroblasts coming from the SVZ. Interestingly, stem cells isolated from the proximal RE generate significantly more oligodendrocytes, and those from the distal RE proliferate significantly more slowly than stem cells derived from the SVZ and other RE regions. These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway.

Original languageEnglish
Pages (from-to)437-445
Number of pages9
JournalJournal of Neuroscience
Volume22
Issue number2
Publication statusPublished - Jan 15 2002

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Multipotent Stem Cells
Neural Stem Cells
Lateral Ventricles
Olfactory Bulb
Rodentia
Stem Cells
Prosencephalon
Neurons
Adult Stem Cells
Oligodendroglia
Neuroglia
Brain

Keywords

  • Adult neural stem cells
  • Forebrain subventricular region
  • Multipotent precursors
  • Neurogenesis
  • Olfactory bulb
  • Rostral extension

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. / Gritti, Angela; Bonfanti, Luca; Doetsch, Fiona; Caille, Isabelle; Alvarez-Buylla, Arturo; Lim, Daniel A.; Galli, Rossella; Verdugo, J. M G; Herrera, Daniel G.; Vescovi, Angelo L.

In: Journal of Neuroscience, Vol. 22, No. 2, 15.01.2002, p. 437-445.

Research output: Contribution to journalArticle

Gritti, A, Bonfanti, L, Doetsch, F, Caille, I, Alvarez-Buylla, A, Lim, DA, Galli, R, Verdugo, JMG, Herrera, DG & Vescovi, AL 2002, 'Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents', Journal of Neuroscience, vol. 22, no. 2, pp. 437-445.
Gritti A, Bonfanti L, Doetsch F, Caille I, Alvarez-Buylla A, Lim DA et al. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. Journal of Neuroscience. 2002 Jan 15;22(2):437-445.
Gritti, Angela ; Bonfanti, Luca ; Doetsch, Fiona ; Caille, Isabelle ; Alvarez-Buylla, Arturo ; Lim, Daniel A. ; Galli, Rossella ; Verdugo, J. M G ; Herrera, Daniel G. ; Vescovi, Angelo L. / Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 2. pp. 437-445.
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