Multispectral imaging technology: Visualize, analyze, phenotyping, and quantify immune cells in situ

Research output: Contribution to journalArticlepeer-review

Abstract

In the personalized medicine era, the field of immunohistopathology is evolving to provide even more precise diagnostic information to efficiently apply targeting therapies. In this regard, MultiSpectral fluorescence Imaging (MSI) is a powerful and reliable technique that provides a detailed and remarkable analysis of multiple biomarkers within their histological context. In particular, the analysis of the immune infiltrate in conjunction with the expression of immune checkpoint molecules could explain why the efficacy of the promising treatments based on immune modulator monoclonal antibodies is still limited. We analyzed the advantages and the pitfalls of applying MSI technology to investigate the immune infiltrate in correlation with programmed death-ligand 1 expression in paraffin embedded ovarian cancer samples.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalThe International journal of biological markers
Volume35
Issue number1_suppl
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Female
  • Humans
  • Immunochemistry/methods
  • Immunophenotyping/methods
  • Male
  • Molecular Imaging/methods

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