Multitasking in tumor progression: Signaling functions of cell adhesion molecules

Ugo Cavallaro, Gerhard Christofori

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Approximately 90% of all cancer deaths arise from metastasis formation. Hence, understanding the molecular mechanisms underlying tumor progression, local invasion, and the formation of tumor metastases represents one of the great challenges in exploratory cancer research. Recent experimental results indicate that changes in cell adhesion play a critical role in tumor progression. Cell adhesion molecules of varying classes and functions, including cadherins, cell adhesion molecules of the immunoglobulin family (Ig-CAMs), CD44, and integrins, can interact with and modulate the signaling function of receptor tyrosine kinases (RTKs). Conversely, signaling by RTKs can directly affect the adhesive function of adhesion molecules. Loss of E-cadherin and gain of mesenchymal cadherin function as well as changes in the expression of Ig-CAMs during the progression of many cancer types exemplify such functional implicatons: cell adhesion molecules not only define a tumor cell's adhesive repertoire, but also directly influence classic signal transduction pathways, thereby modulating the metastatic behavior of tumor cells.

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1014
DOIs
Publication statusPublished - 2004

Fingerprint

Multitasking
Cell Adhesion Molecules
Tumors
Cadherins
Receptor Protein-Tyrosine Kinases
Computer aided manufacturing
Neoplasms
Adhesives
Cells
Signal transduction
Cell adhesion
Integrins
Immunoglobulins
Neoplasm Metastasis
Adhesion
Molecules
Progression
Cell Adhesion
Signal Transduction

Keywords

  • Cadherin
  • CAM
  • Cell adhesion
  • Integrin
  • Metastasis
  • Signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Multitasking in tumor progression : Signaling functions of cell adhesion molecules. / Cavallaro, Ugo; Christofori, Gerhard.

In: Annals of the New York Academy of Sciences, Vol. 1014, 2004, p. 58-66.

Research output: Contribution to journalArticle

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