Multivariate prognostic factors analysis for second-line chemotherapy in advanced biliary tract cancer

L. Fornaro, S. Cereda, G. Aprile, S. Di Girolamo, D. Santini, N. Silvestris, S. Lonardi, F. Leone, M. Milella, C. Vivaldi, C. Belli, F. Bergamo, S. E. Lutrino, R. Filippi, M. Russano, V. Vaccaro, A. E. Brunetti, V. Rotella, A. Falcone, M. A. BarberaJ. Corbelli, G. Fasola, M. Aglietta, V. Zagonel, M. Reni, E. Vasile, G. Brandi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model. Methods: Baseline clinical and laboratory data of 300 consecutive aBTC patients were collected and association with overall survival (OS) was investigated by multivariable Cox models. Results: The following parameters resulted independently associated with longer OS: Eastern Cooperative Oncology Group performance status of 0 (P

Original languageEnglish
Pages (from-to)2165-2169
Number of pages5
JournalBritish Journal of Cancer
Volume110
Issue number9
DOIs
Publication statusPublished - Apr 29 2014

Keywords

  • advanced biliary tract cancer
  • chemotherapy
  • prognostic factors
  • second-line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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