Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems

P. Madeddu, C. Emanueli, F. Spillmann, M. Meloni, N. Bouby, C. Richer, F. Alhenc-Gelas, V. Van Weel, D. Eefting, P. H A Quax, Y. Hu, Q. Xu, A. L. Hemdahl, J. van Golde, M. Huijberts, Q. de Lussanet, H. Struijker Boudier, T. Couffinhal, C. Duplaa, S. ChimentiL. Staszewsky, R. Latini, V. Baumans, B. I. Levy

Research output: Contribution to journalArticle

Abstract

Ischemic disease represents the new epidemic worldwide. Animal models of ischemic disease are useful because they can help us to understand the underlying pathogenetic mechanisms and develop new therapies. The present review article summarizes the results of a consensus conference on the status and future development of experimentation in the field of cardiovascular medicine using murine models of peripheral and myocardial ischemia. The starting point was to recognize the limits of the approach, which mainly derive from species- and disease-related differences in cardiovascular physiology. For instance, the mouse heart beats at a rate 10 times faster than the human heart. Furthermore, healing processes are more rapid in animals, as they rely on mechanisms that may have lost relevance in man. The main objective of the authors was to propose general guidelines, diagnostic end points and relevance to clinical problems.

Original languageEnglish
Pages (from-to)281-301
Number of pages21
JournalVascular Pharmacology
Volume45
Issue number5
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Blood flow
  • Ischemia
  • Mouse models
  • Myocardial infarction
  • Wound healing

ASJC Scopus subject areas

  • Pharmacology

Cite this

Madeddu, P., Emanueli, C., Spillmann, F., Meloni, M., Bouby, N., Richer, C., Alhenc-Gelas, F., Van Weel, V., Eefting, D., Quax, P. H. A., Hu, Y., Xu, Q., Hemdahl, A. L., van Golde, J., Huijberts, M., de Lussanet, Q., Boudier, H. S., Couffinhal, T., Duplaa, C., ... Levy, B. I. (2006). Murine models of myocardial and limb ischemia: Diagnostic end-points and relevance to clinical problems. Vascular Pharmacology, 45(5), 281-301. https://doi.org/10.1016/j.vph.2006.08.008