Muscle carnitine deficiency in patients with severe peripheral vascular disease

Gregorio Brevetti, Corrado Angelini, Maurizio Rosa, Rosalba Carrozzo, Sergio Perna, Marco Corsi, Angelo Matarazzo, Alberto Marcialis

Research output: Contribution to journalArticle

Abstract

Background. This study was designed to evaluate the effect of severe peripheral arterial insufficiency on carnitine concentrations and carnitine acetyltransferase and palmitoyltransferase activities in the ischemic skeletal muscles of patients with severe peripheral vascular disease. Methods and Results. Nine biopsy specimens of ischemic muscles were obtained from five patients undergoing reconstructive vascular surgery. Biopsies from 35 normal subjects served as controls. Ischemic muscles showed a significant reduction in total carnitine from the control value of 20.9±5.2 to 11.6±6.2 nmol/mg noncollagen protein (p

Original languageEnglish
Pages (from-to)1490-1495
Number of pages6
JournalCirculation
Volume84
Issue number4
Publication statusPublished - Oct 1991

Keywords

  • Carnitine acetyltransferase
  • Ischemia
  • L-propionylcarnitine
  • Muscle, skeletal

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Brevetti, G., Angelini, C., Rosa, M., Carrozzo, R., Perna, S., Corsi, M., Matarazzo, A., & Marcialis, A. (1991). Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation, 84(4), 1490-1495.