Muscle fiber degeneration and necrosis in muscular dystrophy and other muscle diseases: Cytochemical and immunocytochemical data

F. Cornelio, I. Dones

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41 Citations (Scopus)

Abstract

Serial consecutive frozen sections from 164 muscle biopsy specimens were studied cytochemically. We localized calcium and albumin as endogenous markers of extracellular fluid penetration and C3 and C9 complement components as markers of muscle fiber necrosis. In both Duchenne dystrophy and congenital muscular dystrophy, a significant percentage of fibers were overloaded with calcium and penetrated by albumin. Most of these fibers appeared opaque with trichrome stain. C3 and C9 complement components appeared only in necrotic fibers, which invariably were also penetrated by albumin. These observations support previous findings that muscle fiber necrosis is linked to massive inflow of extracellular fluid and complement activation. In addition, in both Duchenne and congenital dystrophies, numerous nonnecrotic fibers are penetrated by calcium-rich extracellular fluid.

Original languageEnglish
Pages (from-to)694-701
Number of pages8
JournalAnnals of Neurology
Volume16
Issue number6
Publication statusPublished - 1984

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Muscular Dystrophies
Extracellular Fluid
Complement C9
Albumins
Complement C3
Necrosis
Calcium
Muscles
Complement Activation
Frozen Sections
Biopsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Muscle fiber degeneration and necrosis in muscular dystrophy and other muscle diseases : Cytochemical and immunocytochemical data. / Cornelio, F.; Dones, I.

In: Annals of Neurology, Vol. 16, No. 6, 1984, p. 694-701.

Research output: Contribution to journalArticle

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