Abstract
Morphologic characteristics of the long-term denervated muscle in animals suggest that some original fibers are lost and some of those seen are the result of repeated cycles of fiber regeneration. Muscle biopsies from lower motoneuron denervated patients enrolled in the EU Project RISE show the characteristics of long-term denervation. They present a few atrophic or severely atrophic myofibers dispersed among adipocytes and connective tissue (denervated degenerated muscle, DDM). Monoclonal antibody for embryonic myosin shows that regenerative events are present from 1- to 37-years postspinal cord injury (SCI). After 2- to 10-years FES-training the muscle cryosections present mainly large round myofibers. In the FES-trained muscles the regenerative events are present, but at a lower rate than long-term denervated muscles (myofiber per mm2 of cryosection area: 0.8 ± 1.3 in FES vs. 2.3 ± 2.3 in DDM, mean ± SD, P = 0.011). In our opinion this is a sound additional evidence of effectiveness of the Kern's electrical stimulation protocol for FES of DDM. In any case, the overall results demonstrate that the FES-training is safe: at least it does not induce more myofiber damage/regeneration than denervation per se.
| Original language | English |
|---|---|
| Pages (from-to) | 187-191 |
| Number of pages | 5 |
| Journal | Artificial Organs |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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Keywords
- Functional electrical stimulation
- Human
- Long-term denervation
- Lower motoneuron lesion
- Myofiber regeneration
- Spinal-cord injury
ASJC Scopus subject areas
- Biophysics
Cite this
Muscle fiber regeneration in human permanent lower motoneuron denervation : Relevance to safety and effectiveness of FES-training, which induces muscle recovery in SCI subjects. / Carraro, Ugo; Rossini, Katia; Mayr, Winfried; Kern, Helmut.
In: Artificial Organs, Vol. 29, No. 3, 03.2005, p. 187-191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Muscle fiber regeneration in human permanent lower motoneuron denervation
T2 - Relevance to safety and effectiveness of FES-training, which induces muscle recovery in SCI subjects
AU - Carraro, Ugo
AU - Rossini, Katia
AU - Mayr, Winfried
AU - Kern, Helmut
PY - 2005/3
Y1 - 2005/3
N2 - Morphologic characteristics of the long-term denervated muscle in animals suggest that some original fibers are lost and some of those seen are the result of repeated cycles of fiber regeneration. Muscle biopsies from lower motoneuron denervated patients enrolled in the EU Project RISE show the characteristics of long-term denervation. They present a few atrophic or severely atrophic myofibers dispersed among adipocytes and connective tissue (denervated degenerated muscle, DDM). Monoclonal antibody for embryonic myosin shows that regenerative events are present from 1- to 37-years postspinal cord injury (SCI). After 2- to 10-years FES-training the muscle cryosections present mainly large round myofibers. In the FES-trained muscles the regenerative events are present, but at a lower rate than long-term denervated muscles (myofiber per mm2 of cryosection area: 0.8 ± 1.3 in FES vs. 2.3 ± 2.3 in DDM, mean ± SD, P = 0.011). In our opinion this is a sound additional evidence of effectiveness of the Kern's electrical stimulation protocol for FES of DDM. In any case, the overall results demonstrate that the FES-training is safe: at least it does not induce more myofiber damage/regeneration than denervation per se.
AB - Morphologic characteristics of the long-term denervated muscle in animals suggest that some original fibers are lost and some of those seen are the result of repeated cycles of fiber regeneration. Muscle biopsies from lower motoneuron denervated patients enrolled in the EU Project RISE show the characteristics of long-term denervation. They present a few atrophic or severely atrophic myofibers dispersed among adipocytes and connective tissue (denervated degenerated muscle, DDM). Monoclonal antibody for embryonic myosin shows that regenerative events are present from 1- to 37-years postspinal cord injury (SCI). After 2- to 10-years FES-training the muscle cryosections present mainly large round myofibers. In the FES-trained muscles the regenerative events are present, but at a lower rate than long-term denervated muscles (myofiber per mm2 of cryosection area: 0.8 ± 1.3 in FES vs. 2.3 ± 2.3 in DDM, mean ± SD, P = 0.011). In our opinion this is a sound additional evidence of effectiveness of the Kern's electrical stimulation protocol for FES of DDM. In any case, the overall results demonstrate that the FES-training is safe: at least it does not induce more myofiber damage/regeneration than denervation per se.
KW - Functional electrical stimulation
KW - Human
KW - Long-term denervation
KW - Lower motoneuron lesion
KW - Myofiber regeneration
KW - Spinal-cord injury
UR - http://www.scopus.com/inward/record.url?scp=20644450782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20644450782&partnerID=8YFLogxK
U2 - 10.1111/j.1525-1594.2005.29032.x
DO - 10.1111/j.1525-1594.2005.29032.x
M3 - Article
C2 - 15725214
AN - SCOPUS:20644450782
VL - 29
SP - 187
EP - 191
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 3
ER -