Muscle metabolic alterations assessed by 31-phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy

Michela Tosetti; Stefania Linsalata; Roberta Battini; Leda Volpi; Claudio Cini; Otello Presciutti; Francesco Muntoni; Giovanni Cioni; Gabriele Siciliano

doi:10.1002/mus.22181

Muscle metabolic alterations assessed by 31-phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy

Michela Tosetti, Stefania Linsalata, Roberta Battini, Leda Volpi, Claudio Cini, Otello Presciutti, Francesco Muntoni, Giovanni Cioni, Gabriele Siciliano

Fondazione Stella Maris

Research output: Contribution to journal › Article › peer-review

Abstract

Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise-related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31-phosphorus magnetic resonance spectroscopy (31P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery.

Original language	English
Pages (from-to)	816-819
Number of pages	4
Journal	Muscle and Nerve
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/mus.22181
Publication status	Published - Nov 2011

Keywords

31-phosphorus magnetic resonance spectroscopy
Becker muscular dystrophy
Exercising muscle
Muscular energy metabolism
Phosphocreatine

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology

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10.1002/mus.22181

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Muscle metabolic alterations assessed by 31-phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy. / Tosetti, Michela; Linsalata, Stefania; Battini, Roberta; Volpi, Leda; Cini, Claudio; Presciutti, Otello; Muntoni, Francesco; Cioni, Giovanni; Siciliano, Gabriele.

In: Muscle and Nerve, Vol. 44, No. 5, 11.2011, p. 816-819.

Research output: Contribution to journal › Article › peer-review

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abstract = "Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise-related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31-phosphorus magnetic resonance spectroscopy (31P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery.",

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AU - Volpi, Leda

AU - Cini, Claudio

AU - Presciutti, Otello

AU - Muntoni, Francesco

AU - Cioni, Giovanni

AU - Siciliano, Gabriele

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KW - Exercising muscle

KW - Muscular energy metabolism

KW - Phosphocreatine

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Muscle metabolic alterations assessed by 31-phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy

Abstract

Keywords

ASJC Scopus subject areas

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