Muscle metabolic alterations assessed by 31-phosphorus magnetic resonance spectroscopy in mild becker muscular dystrophy

Michela Tosetti, Stefania Linsalata, Roberta Battini, Leda Volpi, Claudio Cini, Otello Presciutti, Francesco Muntoni, Giovanni Cioni, Gabriele Siciliano

Research output: Contribution to journalArticlepeer-review

Abstract

Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise-related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31-phosphorus magnetic resonance spectroscopy (31P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery.

Original languageEnglish
Pages (from-to)816-819
Number of pages4
JournalMuscle and Nerve
Volume44
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • 31-phosphorus magnetic resonance spectroscopy
  • Becker muscular dystrophy
  • Exercising muscle
  • Muscular energy metabolism
  • Phosphocreatine

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

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