Abstract
Although the molecular defect causing Becker muscular dystrophy (BMD) has been identified, the biochemical mechanisms that lead to muscle necrosis remain unclear. Exercise-related muscle metabolism in 9 mildly affected BMD patients was assessed by muscle 31-phosphorus magnetic resonance spectroscopy (31P MRS) during an incremental workload. Compared with normal controls, BMD patients showed deregulation of resting pH and intramuscular membrane breakdown. We also observed increased reliance upon anaerobic metabolism during sustained submaximal contraction and maintenance of oxidative function during recovery.
Original language | English |
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Pages (from-to) | 816-819 |
Number of pages | 4 |
Journal | Muscle and Nerve |
Volume | 44 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 2011 |
Keywords
- 31-phosphorus magnetic resonance spectroscopy
- Becker muscular dystrophy
- Exercising muscle
- Muscular energy metabolism
- Phosphocreatine
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)
- Physiology