Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise

Javier A. Sala-Mercado, Masashi Ichinose, Robert L. Hammond, Tomoko Ichinose, Marco Pallante, Larry W. Stephenson, Donal S. O'Leary, Ferdinando Iellamo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hypoperfusion of active skeletal muscle elicits a reflex pressor response termed the muscle metaboreflex. Dynamic exercise attenuates spontaneous baroreflex sensitivity (SBRS) in the control of heart rate (HR) during rapid, spontaneous changes in blood pressure (BP). Our objective was to determine whether muscle metaboreflex activation (MRA) further diminishes SBRS. Conscious dogs were chronically instrumented for measurement of HR, cardiac output, mean arterial pressure, and left ventricular systolic pressure (LVSP) at rest and during mild (3.2 km/h) or moderate (6.4 km/h at 10% grade) dynamic exercise before and after MRA (via partial reduction of hindlimb blood flow). SBRS was evaluated as the slopes of the linear relations (LRs) between HR and LVSP during spontaneous sequences of at least three consecutive beats when HR changed inversely vs. pressure (expressed as beats ·min -1·mmHg-1). During mild exercise, these LRs shifted upward, with a significant decrease in SBRS (-3.0 ± 0.4 vs. -5.2 ± 0.4, P <0.05 vs. rest). MRA shifted LRs upward and rightward and decreased SBRS (-2.1 ± 0.1, P <0.05 vs. mild exercise). Moderate exercise shifted LRs upward and rightward and significantly decreased SBRS (-1.2 ± 0.1, P <0.05 vs. rest). MRA elicited further upward and rightward shifts of the LRs and reductions in SBRS (-0.9 ± 0.1, P <0.05 vs. moderate exercise). We conclude that dynamic exercise resets the arterial baroreflex to higher BP and HR as exercise intensity increases. In addition, increases in exercise intensity, as well as MRA, attenuate SBRS.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume292
Issue number6
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Baroreflex
Heart Rate
Muscles
Ventricular Pressure
Blood Pressure
Hindlimb
Cardiac Output
Reflex
Arterial Pressure
Skeletal Muscle
Dogs
Hypertension
Pressure

Keywords

  • Arterial baroreflex sensitivity
  • Exercise reflexes
  • Heart rate variability
  • Pressor response

ASJC Scopus subject areas

  • Physiology

Cite this

Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise. / Sala-Mercado, Javier A.; Ichinose, Masashi; Hammond, Robert L.; Ichinose, Tomoko; Pallante, Marco; Stephenson, Larry W.; O'Leary, Donal S.; Iellamo, Ferdinando.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 292, No. 6, 06.2007.

Research output: Contribution to journalArticle

Sala-Mercado, Javier A. ; Ichinose, Masashi ; Hammond, Robert L. ; Ichinose, Tomoko ; Pallante, Marco ; Stephenson, Larry W. ; O'Leary, Donal S. ; Iellamo, Ferdinando. / Muscle metaboreflex attenuates spontaneous heart rate baroreflex sensitivity during dynamic exercise. In: American Journal of Physiology - Heart and Circulatory Physiology. 2007 ; Vol. 292, No. 6.
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AB - Hypoperfusion of active skeletal muscle elicits a reflex pressor response termed the muscle metaboreflex. Dynamic exercise attenuates spontaneous baroreflex sensitivity (SBRS) in the control of heart rate (HR) during rapid, spontaneous changes in blood pressure (BP). Our objective was to determine whether muscle metaboreflex activation (MRA) further diminishes SBRS. Conscious dogs were chronically instrumented for measurement of HR, cardiac output, mean arterial pressure, and left ventricular systolic pressure (LVSP) at rest and during mild (3.2 km/h) or moderate (6.4 km/h at 10% grade) dynamic exercise before and after MRA (via partial reduction of hindlimb blood flow). SBRS was evaluated as the slopes of the linear relations (LRs) between HR and LVSP during spontaneous sequences of at least three consecutive beats when HR changed inversely vs. pressure (expressed as beats ·min -1·mmHg-1). During mild exercise, these LRs shifted upward, with a significant decrease in SBRS (-3.0 ± 0.4 vs. -5.2 ± 0.4, P <0.05 vs. rest). MRA shifted LRs upward and rightward and decreased SBRS (-2.1 ± 0.1, P <0.05 vs. mild exercise). Moderate exercise shifted LRs upward and rightward and significantly decreased SBRS (-1.2 ± 0.1, P <0.05 vs. rest). MRA elicited further upward and rightward shifts of the LRs and reductions in SBRS (-0.9 ± 0.1, P <0.05 vs. moderate exercise). We conclude that dynamic exercise resets the arterial baroreflex to higher BP and HR as exercise intensity increases. In addition, increases in exercise intensity, as well as MRA, attenuate SBRS.

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