Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient

N. Bresolin, P. Martinelli, B. Barbiroli, P. Zaniol, C. Ausenda, P. Montagna, A. Gallanti, G. P. Comi, G. Scarlato, E. Lugaresi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

A 40-year-old female suffering from recurrent migrainous strokes is reported. She did not show any muscle weakness or wasting. Ragged red and cytochrome c oxidase negative fibers were present in the muscle biopsy. Muscle mitochondrial DNA analysis showed a 5 kb deletion, without a point mutation at nucleotide pair 3243 in the mitochondrial tRNALeu(UUR) gene. Phosphorus nuclear magnetic resonance spectroscopy of brain and gastrocnemius muscle showed a defective energy metabolism in both organs. An increased inorganic phosphate to phosphocreatine ratio due to a decreased phosphocreatine content was found in the occipital lobes, while an abnormal work-energy cost transfer function and a low rate of phosphocreatine post-exercise recovery were found in the muscle.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalJournal of the Neurological Sciences
Volume104
Issue number2
DOIs
Publication statusPublished - 1991

Fingerprint

Phosphocreatine
Migraine Disorders
Mitochondrial DNA
Magnetic Resonance Spectroscopy
Muscles
RNA, Transfer, Leu
Occipital Lobe
Energy Transfer
Muscle Weakness
Electron Transport Complex IV
Point Mutation
Phosphorus
Energy Metabolism
Skeletal Muscle
Nucleotides
Stroke
Phosphates
Exercise
Biopsy
Costs and Cost Analysis

Keywords

  • P-NMR spectroscopy
  • Brain bioenergetics
  • Migraine
  • Mitochondrial encephalomyopathy
  • mtDNA deletion
  • Muscle energy metabolism

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient. / Bresolin, N.; Martinelli, P.; Barbiroli, B.; Zaniol, P.; Ausenda, C.; Montagna, P.; Gallanti, A.; Comi, G. P.; Scarlato, G.; Lugaresi, E.

In: Journal of the Neurological Sciences, Vol. 104, No. 2, 1991, p. 182-189.

Research output: Contribution to journalArticle

Bresolin, N, Martinelli, P, Barbiroli, B, Zaniol, P, Ausenda, C, Montagna, P, Gallanti, A, Comi, GP, Scarlato, G & Lugaresi, E 1991, 'Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient', Journal of the Neurological Sciences, vol. 104, no. 2, pp. 182-189. https://doi.org/10.1016/0022-510X(91)90308-T
Bresolin, N. ; Martinelli, P. ; Barbiroli, B. ; Zaniol, P. ; Ausenda, C. ; Montagna, P. ; Gallanti, A. ; Comi, G. P. ; Scarlato, G. ; Lugaresi, E. / Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient. In: Journal of the Neurological Sciences. 1991 ; Vol. 104, No. 2. pp. 182-189.
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