Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients

Anna Maria Malagoni, Michele Felisatti, Nicola Lamberti, Nino Basaglia, Roberto Manfredini, Fabrizio Salvi, Paolo Zamboni, Fabio Manfredini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate its possible relationship with patients' mobility.Methods: Twenty-eight consecutively enrolled MS patients (male, n = 16; age = 42.7 ± 14.0 y, Relapsing-Remitting, n = 19; Primary-Progressive, n = 9) and 22 HC (male, n = 13; age = 36.0 ± 8.2 y) were studied during rest applying the NIRS probes at gastrocnemius, producing a venous occlusion at the thigh using a cuff, and analyzing the slope of the total hemoglobin to calculate rmVO2. Mobility was assessed by a 6-Minute Walking Test and 6-Minute Walking Distance (6MWD) was recorded.Results: rmVO2 was higher in MS compared to HC (0.059 ± 0.038 vs 0.039 ± 0.016 mlO2/min/100 g, P <0.003), not different in clinical subtypes, not correlated to patients' characteristics (age, disease duration, Expanded Disability Status Scale, resting heart rate, skinfold thickness), and significantly higher in patients with lower walking ability (6MWD <450 m, n = 12) compared to those at better performance (respectively, 0.072 ± 0.043 vs 0.049 ± 0.032 mlO2/min/100 g, P = 0.03).Conclusion: rmVO2 values, significantly higher in MS patients compared to HC, and in low versus high performing patients, might represent a marker of peripheral adaptations occurred to sustain mobility, as observed in other chronic diseases.

Original languageEnglish
Article number52
JournalBMC Neurology
Volume13
DOIs
Publication statusPublished - May 29 2013

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Near-Infrared Spectroscopy
Oxygen Consumption
Multiple Sclerosis
Muscles
Walking
Skinfold Thickness
Thigh
Hemoglobins
Chronic Disease
Heart Rate

Keywords

  • Multiple sclerosis
  • Muscle metabolism
  • Near-infrared spectroscopy
  • Non-invasive
  • Oxygen consumption

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Malagoni, A. M., Felisatti, M., Lamberti, N., Basaglia, N., Manfredini, R., Salvi, F., ... Manfredini, F. (2013). Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients. BMC Neurology, 13, [52]. https://doi.org/10.1186/1471-2377-13-52

Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients. / Malagoni, Anna Maria; Felisatti, Michele; Lamberti, Nicola; Basaglia, Nino; Manfredini, Roberto; Salvi, Fabrizio; Zamboni, Paolo; Manfredini, Fabio.

In: BMC Neurology, Vol. 13, 52, 29.05.2013.

Research output: Contribution to journalArticle

Malagoni, AM, Felisatti, M, Lamberti, N, Basaglia, N, Manfredini, R, Salvi, F, Zamboni, P & Manfredini, F 2013, 'Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients', BMC Neurology, vol. 13, 52. https://doi.org/10.1186/1471-2377-13-52
Malagoni AM, Felisatti M, Lamberti N, Basaglia N, Manfredini R, Salvi F et al. Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients. BMC Neurology. 2013 May 29;13. 52. https://doi.org/10.1186/1471-2377-13-52
Malagoni, Anna Maria ; Felisatti, Michele ; Lamberti, Nicola ; Basaglia, Nino ; Manfredini, Roberto ; Salvi, Fabrizio ; Zamboni, Paolo ; Manfredini, Fabio. / Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients. In: BMC Neurology. 2013 ; Vol. 13.
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abstract = "Background: The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate its possible relationship with patients' mobility.Methods: Twenty-eight consecutively enrolled MS patients (male, n = 16; age = 42.7 ± 14.0 y, Relapsing-Remitting, n = 19; Primary-Progressive, n = 9) and 22 HC (male, n = 13; age = 36.0 ± 8.2 y) were studied during rest applying the NIRS probes at gastrocnemius, producing a venous occlusion at the thigh using a cuff, and analyzing the slope of the total hemoglobin to calculate rmVO2. Mobility was assessed by a 6-Minute Walking Test and 6-Minute Walking Distance (6MWD) was recorded.Results: rmVO2 was higher in MS compared to HC (0.059 ± 0.038 vs 0.039 ± 0.016 mlO2/min/100 g, P <0.003), not different in clinical subtypes, not correlated to patients' characteristics (age, disease duration, Expanded Disability Status Scale, resting heart rate, skinfold thickness), and significantly higher in patients with lower walking ability (6MWD <450 m, n = 12) compared to those at better performance (respectively, 0.072 ± 0.043 vs 0.049 ± 0.032 mlO2/min/100 g, P = 0.03).Conclusion: rmVO2 values, significantly higher in MS patients compared to HC, and in low versus high performing patients, might represent a marker of peripheral adaptations occurred to sustain mobility, as observed in other chronic diseases.",
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AU - Lamberti, Nicola

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AU - Manfredini, Roberto

AU - Salvi, Fabrizio

AU - Zamboni, Paolo

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