Muscle synergy patterns as physiological markers of motor cortical damage.

Vincent C K Cheung, Andrea Turolla, Michela Agostini, Stefano Silvoni, Caoimhe Bennis, Patrick Kasi, Sabrina Paganoni, Paolo Bonato, Emilio Bizzi

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the flow of descending signals to the modular interneuronal structures of the spinal cord. These spinal modules subserve normal motor behaviors by activating groups of muscles as individual units (muscle synergies). Damage to the motor cortical areas disrupts the orchestration of the modules, resulting in abnormal movements. To gain insights into this complex process, we recorded myoelectric signals from multiple upper-limb muscles in subjects with cortical lesions. We used a factorization algorithm to identify the muscle synergies. Our factorization analysis revealed, in a quantitative way, three distinct patterns of muscle coordination-including preservation, merging, and fractionation of muscle synergies-that reflect the multiple neural responses that occur after cortical damage. These patterns varied as a function of both the severity of functional impairment and the temporal distance from stroke onset. We think these muscle-synergy patterns can be used as physiological markers of the status of any patient with stroke or trauma, thereby guiding the development of different rehabilitation approaches, as well as future physiological experiments for a further understanding of postinjury mechanisms of motor control and recovery.

Original languageEnglish
Pages (from-to)14652-14656
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number36
Publication statusPublished - Sep 4 2012

Fingerprint

Muscles
Stroke
Motor Cortex
Dyskinesias
Wounds and Injuries
Upper Extremity
Spinal Cord
Rehabilitation

ASJC Scopus subject areas

  • General

Cite this

Muscle synergy patterns as physiological markers of motor cortical damage. / Cheung, Vincent C K; Turolla, Andrea; Agostini, Michela; Silvoni, Stefano; Bennis, Caoimhe; Kasi, Patrick; Paganoni, Sabrina; Bonato, Paolo; Bizzi, Emilio.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 36, 04.09.2012, p. 14652-14656.

Research output: Contribution to journalArticle

Cheung, VCK, Turolla, A, Agostini, M, Silvoni, S, Bennis, C, Kasi, P, Paganoni, S, Bonato, P & Bizzi, E 2012, 'Muscle synergy patterns as physiological markers of motor cortical damage.', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 36, pp. 14652-14656.
Cheung, Vincent C K ; Turolla, Andrea ; Agostini, Michela ; Silvoni, Stefano ; Bennis, Caoimhe ; Kasi, Patrick ; Paganoni, Sabrina ; Bonato, Paolo ; Bizzi, Emilio. / Muscle synergy patterns as physiological markers of motor cortical damage. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 36. pp. 14652-14656.
@article{a6d1a1f108044aa799d4c6e509ed37eb,
title = "Muscle synergy patterns as physiological markers of motor cortical damage.",
abstract = "The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the flow of descending signals to the modular interneuronal structures of the spinal cord. These spinal modules subserve normal motor behaviors by activating groups of muscles as individual units (muscle synergies). Damage to the motor cortical areas disrupts the orchestration of the modules, resulting in abnormal movements. To gain insights into this complex process, we recorded myoelectric signals from multiple upper-limb muscles in subjects with cortical lesions. We used a factorization algorithm to identify the muscle synergies. Our factorization analysis revealed, in a quantitative way, three distinct patterns of muscle coordination-including preservation, merging, and fractionation of muscle synergies-that reflect the multiple neural responses that occur after cortical damage. These patterns varied as a function of both the severity of functional impairment and the temporal distance from stroke onset. We think these muscle-synergy patterns can be used as physiological markers of the status of any patient with stroke or trauma, thereby guiding the development of different rehabilitation approaches, as well as future physiological experiments for a further understanding of postinjury mechanisms of motor control and recovery.",
author = "Cheung, {Vincent C K} and Andrea Turolla and Michela Agostini and Stefano Silvoni and Caoimhe Bennis and Patrick Kasi and Sabrina Paganoni and Paolo Bonato and Emilio Bizzi",
year = "2012",
month = "9",
day = "4",
language = "English",
volume = "109",
pages = "14652--14656",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "36",

}

TY - JOUR

T1 - Muscle synergy patterns as physiological markers of motor cortical damage.

AU - Cheung, Vincent C K

AU - Turolla, Andrea

AU - Agostini, Michela

AU - Silvoni, Stefano

AU - Bennis, Caoimhe

AU - Kasi, Patrick

AU - Paganoni, Sabrina

AU - Bonato, Paolo

AU - Bizzi, Emilio

PY - 2012/9/4

Y1 - 2012/9/4

N2 - The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the flow of descending signals to the modular interneuronal structures of the spinal cord. These spinal modules subserve normal motor behaviors by activating groups of muscles as individual units (muscle synergies). Damage to the motor cortical areas disrupts the orchestration of the modules, resulting in abnormal movements. To gain insights into this complex process, we recorded myoelectric signals from multiple upper-limb muscles in subjects with cortical lesions. We used a factorization algorithm to identify the muscle synergies. Our factorization analysis revealed, in a quantitative way, three distinct patterns of muscle coordination-including preservation, merging, and fractionation of muscle synergies-that reflect the multiple neural responses that occur after cortical damage. These patterns varied as a function of both the severity of functional impairment and the temporal distance from stroke onset. We think these muscle-synergy patterns can be used as physiological markers of the status of any patient with stroke or trauma, thereby guiding the development of different rehabilitation approaches, as well as future physiological experiments for a further understanding of postinjury mechanisms of motor control and recovery.

AB - The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the flow of descending signals to the modular interneuronal structures of the spinal cord. These spinal modules subserve normal motor behaviors by activating groups of muscles as individual units (muscle synergies). Damage to the motor cortical areas disrupts the orchestration of the modules, resulting in abnormal movements. To gain insights into this complex process, we recorded myoelectric signals from multiple upper-limb muscles in subjects with cortical lesions. We used a factorization algorithm to identify the muscle synergies. Our factorization analysis revealed, in a quantitative way, three distinct patterns of muscle coordination-including preservation, merging, and fractionation of muscle synergies-that reflect the multiple neural responses that occur after cortical damage. These patterns varied as a function of both the severity of functional impairment and the temporal distance from stroke onset. We think these muscle-synergy patterns can be used as physiological markers of the status of any patient with stroke or trauma, thereby guiding the development of different rehabilitation approaches, as well as future physiological experiments for a further understanding of postinjury mechanisms of motor control and recovery.

UR - http://www.scopus.com/inward/record.url?scp=84871692964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871692964&partnerID=8YFLogxK

M3 - Article

VL - 109

SP - 14652

EP - 14656

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 36

ER -