Muscle wasting in heart failure: An overview

Stephan von Haehling, Lisa Steinbeck, Wolfram Doehner, Jochen Springer, Stefan D. Anker

Research output: Contribution to journalArticle

Abstract

Patients with heart failure are frequently limited in their exercise capacity. Although this clinical phenomenon is mostly attributed to the failing myocardium, the effects of skeletal muscle wasting should not be underestimated. Muscle wasting may present in the form of loss of muscle mass and function, termed sarcopenia in healthy aging, or in the form of cachexia. Only cachexia is associated with loss of body weight. The mechanisms involved embrace an anabolic-/catabolic imbalance with increased degradation of myofibrils and myocyte apoptosis. Clinical effects include reduced muscle mass, strength and consequently reduced exercise capacity. This article describes the terminology, molecular pathways, prevalence, clinical implications and possible treatment approaches to muscle wasting in patients with heart failure. This article is part of a Directed Issue entitled: Muscle wasting.

Original languageEnglish
JournalInternational Journal of Biochemistry and Cell Biology
DOIs
Publication statusAccepted/In press - 2013

Fingerprint

Muscle
Heart Failure
Muscles
Cachexia
Exercise
Sarcopenia
Critical Pathways
Myofibrils
Muscle Strength
Terminology
Muscle Cells
Myocardium
Skeletal Muscle
Body Weight
Apoptosis
Aging of materials
Degradation
Therapeutics

Keywords

  • Cachexia
  • Heart failure
  • Mechanism
  • Muscle wasting
  • Sarcopenia

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry

Cite this

von Haehling, S., Steinbeck, L., Doehner, W., Springer, J., & Anker, S. D. (Accepted/In press). Muscle wasting in heart failure: An overview. International Journal of Biochemistry and Cell Biology. https://doi.org/10.1016/j.biocel.2013.04.025

Muscle wasting in heart failure : An overview. / von Haehling, Stephan; Steinbeck, Lisa; Doehner, Wolfram; Springer, Jochen; Anker, Stefan D.

In: International Journal of Biochemistry and Cell Biology, 2013.

Research output: Contribution to journalArticle

von Haehling, Stephan ; Steinbeck, Lisa ; Doehner, Wolfram ; Springer, Jochen ; Anker, Stefan D. / Muscle wasting in heart failure : An overview. In: International Journal of Biochemistry and Cell Biology. 2013.
@article{f73ab4e6fc264eb2bcfdf243a7ad325f,
title = "Muscle wasting in heart failure: An overview",
abstract = "Patients with heart failure are frequently limited in their exercise capacity. Although this clinical phenomenon is mostly attributed to the failing myocardium, the effects of skeletal muscle wasting should not be underestimated. Muscle wasting may present in the form of loss of muscle mass and function, termed sarcopenia in healthy aging, or in the form of cachexia. Only cachexia is associated with loss of body weight. The mechanisms involved embrace an anabolic-/catabolic imbalance with increased degradation of myofibrils and myocyte apoptosis. Clinical effects include reduced muscle mass, strength and consequently reduced exercise capacity. This article describes the terminology, molecular pathways, prevalence, clinical implications and possible treatment approaches to muscle wasting in patients with heart failure. This article is part of a Directed Issue entitled: Muscle wasting.",
keywords = "Cachexia, Heart failure, Mechanism, Muscle wasting, Sarcopenia",
author = "{von Haehling}, Stephan and Lisa Steinbeck and Wolfram Doehner and Jochen Springer and Anker, {Stefan D.}",
year = "2013",
doi = "10.1016/j.biocel.2013.04.025",
language = "English",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Muscle wasting in heart failure

T2 - An overview

AU - von Haehling, Stephan

AU - Steinbeck, Lisa

AU - Doehner, Wolfram

AU - Springer, Jochen

AU - Anker, Stefan D.

PY - 2013

Y1 - 2013

N2 - Patients with heart failure are frequently limited in their exercise capacity. Although this clinical phenomenon is mostly attributed to the failing myocardium, the effects of skeletal muscle wasting should not be underestimated. Muscle wasting may present in the form of loss of muscle mass and function, termed sarcopenia in healthy aging, or in the form of cachexia. Only cachexia is associated with loss of body weight. The mechanisms involved embrace an anabolic-/catabolic imbalance with increased degradation of myofibrils and myocyte apoptosis. Clinical effects include reduced muscle mass, strength and consequently reduced exercise capacity. This article describes the terminology, molecular pathways, prevalence, clinical implications and possible treatment approaches to muscle wasting in patients with heart failure. This article is part of a Directed Issue entitled: Muscle wasting.

AB - Patients with heart failure are frequently limited in their exercise capacity. Although this clinical phenomenon is mostly attributed to the failing myocardium, the effects of skeletal muscle wasting should not be underestimated. Muscle wasting may present in the form of loss of muscle mass and function, termed sarcopenia in healthy aging, or in the form of cachexia. Only cachexia is associated with loss of body weight. The mechanisms involved embrace an anabolic-/catabolic imbalance with increased degradation of myofibrils and myocyte apoptosis. Clinical effects include reduced muscle mass, strength and consequently reduced exercise capacity. This article describes the terminology, molecular pathways, prevalence, clinical implications and possible treatment approaches to muscle wasting in patients with heart failure. This article is part of a Directed Issue entitled: Muscle wasting.

KW - Cachexia

KW - Heart failure

KW - Mechanism

KW - Muscle wasting

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=84878310400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878310400&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2013.04.025

DO - 10.1016/j.biocel.2013.04.025

M3 - Article

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

ER -