Muscles cannot break a NuRDy heart

Barbora Malecova, Alessandra Dall'Agnese, Pier Lorenzo Puri

Research output: Contribution to journalArticlepeer-review


The recent article from Gómez-del Arco et al () in Cell Metabolism reveals the essential role of chromodomain-helicase-DNA-binding protein 4 (CHD4) in the control of alternative gene expression in cell types that share seemingly redundant, yet distinct, biological properties, such as the contractile activities of striated cardiac or skeletal muscles. An altered expression of genes for alternative sarcomeric and metabolic programs occurred upon genetic inactivation of Chd4 in skeletal or cardiac cells, leading to formation of “hybrid” striated muscles and pathological outcomes.

Original languageEnglish
Pages (from-to)1600-1602
Number of pages3
JournalEMBO Journal
Issue number15
Publication statusPublished - Aug 1 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)


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