Musculoskeletal aging, sarcopenia, and cancer

Research output: Chapter in Book/Report/Conference proceedingChapter


The decrease in muscle mass and strength represents one of the most relevant descriptor of physiological aging. Sarcopenia is the term coined to indicate the pathologic loss of skeletal muscle mass and strength/function during aging. The skeletal muscle decline has a multifactorial origin, involving lifestyle habits, disease triggers, and age-dependent biological changes. This phenomenon is part of the geriatric background and is today starting to disseminate in other specialties dealing with the complexity of frail older persons. In the oncology field, the interest in muscle wasting has mostly been focused on the clinical entity of cancer cachexia, a complex metabolic syndrome characterized by severe muscle loss, systemic inflammation, and malnutrition. The study of body composition in the oncological setting is crucial and may become one of the main characterizations of the oncogeriatric field, where clinical and research actions have to be designed taking into account the consequences of the aging process.

Original languageEnglish
Title of host publicationGeriatric Oncology
PublisherSpringer International Publishing AG
Number of pages17
ISBN (Electronic)9783319574158
ISBN (Print)9783319574141
Publication statusPublished - Jan 1 2020


  • Aging
  • Body composition
  • Cachexia
  • Muscle
  • Physical function

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Cesari, M., Calvani, R., & Marzetti, E. (2020). Musculoskeletal aging, sarcopenia, and cancer. In Geriatric Oncology (pp. 269-285). Springer International Publishing AG.