Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients

C. Salvarani, I. G. Vlachonikolis, D. M. Van der Heijde, G. Fornaciari, P. Macchioni, M. Beltrami, I. Olivieri, F. Di Gennaro, P. Politi, R. W. Stockbrügger, M. G. Russel

Research output: Contribution to journalArticle

Abstract

Background: Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in an inception cohort of European IBD patients. Methods: From 1 October 1991 to 30 September 1993, 202 IBD patients were diagnosed in three centres of two countries (Italy and The Netherlands) by means of a population-based inception cohort study. Of this group of patients, 160 (79%) were interviewed and examined by a rheumatologist and a gastroenterologist in the period June-September 1996. A total of 139/160 patients had an anteroposterior radiograph of the pelvis, and in 140/160 HLA-B27 was determined. Results: 53 (33.1%) of the 160 patients had experienced at least one musculoskeletal manifestation, 29 (18.1%) satisfied the European Spondylarthropathy Study Group (ESSG) criteria for spondylarthropathy and 5 (3.1%) satisfied the modified New York criteria for ankylosing spondylitis. However, 23 (14.4%) patients developed one or more spondylarthropathy-related manifestations without fulfilling any of the classification criteria. In patients satisfying ESSG criteria a significantly higher frequency of women (P = 0.03), of ocular and liver involvement (P = 0.01 and P = 0.03, respectively), and use of immunosuppressive drugs (P = 0.02) was observed. Conclusion: Our study shows a high prevalence of musculoskeletal manifestations in an inception cohort of IBD patients. The clinical spectrum is broader than that defined by spondylarthropathy criteria.

Original languageEnglish
Pages (from-to)1307-1313
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume36
Issue number12
DOIs
Publication statusPublished - 2001

Fingerprint

Inflammatory Bowel Diseases
Spondylarthropathies
Population
HLA-B27 Antigen
Ankylosing Spondylitis
Immunosuppressive Agents
Pelvis
Netherlands
Patient Selection
Italy
Cohort Studies
Liver
Pharmaceutical Preparations

Keywords

  • Crohn disease
  • Epidemiology
  • Extra-intestinal manifestations
  • Inflammatory bowel disease
  • Spondylarthropathy
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Salvarani, C., Vlachonikolis, I. G., Van der Heijde, D. M., Fornaciari, G., Macchioni, P., Beltrami, M., ... Russel, M. G. (2001). Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients. Scandinavian Journal of Gastroenterology, 36(12), 1307-1313. https://doi.org/10.1080/003655201317097173

Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients. / Salvarani, C.; Vlachonikolis, I. G.; Van der Heijde, D. M.; Fornaciari, G.; Macchioni, P.; Beltrami, M.; Olivieri, I.; Di Gennaro, F.; Politi, P.; Stockbrügger, R. W.; Russel, M. G.

In: Scandinavian Journal of Gastroenterology, Vol. 36, No. 12, 2001, p. 1307-1313.

Research output: Contribution to journalArticle

Salvarani, C, Vlachonikolis, IG, Van der Heijde, DM, Fornaciari, G, Macchioni, P, Beltrami, M, Olivieri, I, Di Gennaro, F, Politi, P, Stockbrügger, RW & Russel, MG 2001, 'Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients', Scandinavian Journal of Gastroenterology, vol. 36, no. 12, pp. 1307-1313. https://doi.org/10.1080/003655201317097173
Salvarani C, Vlachonikolis IG, Van der Heijde DM, Fornaciari G, Macchioni P, Beltrami M et al. Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients. Scandinavian Journal of Gastroenterology. 2001;36(12):1307-1313. https://doi.org/10.1080/003655201317097173
Salvarani, C. ; Vlachonikolis, I. G. ; Van der Heijde, D. M. ; Fornaciari, G. ; Macchioni, P. ; Beltrami, M. ; Olivieri, I. ; Di Gennaro, F. ; Politi, P. ; Stockbrügger, R. W. ; Russel, M. G. / Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients. In: Scandinavian Journal of Gastroenterology. 2001 ; Vol. 36, No. 12. pp. 1307-1313.
@article{b3d448c73d674f53a03d06c4540299fe,
title = "Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients",
abstract = "Background: Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in an inception cohort of European IBD patients. Methods: From 1 October 1991 to 30 September 1993, 202 IBD patients were diagnosed in three centres of two countries (Italy and The Netherlands) by means of a population-based inception cohort study. Of this group of patients, 160 (79{\%}) were interviewed and examined by a rheumatologist and a gastroenterologist in the period June-September 1996. A total of 139/160 patients had an anteroposterior radiograph of the pelvis, and in 140/160 HLA-B27 was determined. Results: 53 (33.1{\%}) of the 160 patients had experienced at least one musculoskeletal manifestation, 29 (18.1{\%}) satisfied the European Spondylarthropathy Study Group (ESSG) criteria for spondylarthropathy and 5 (3.1{\%}) satisfied the modified New York criteria for ankylosing spondylitis. However, 23 (14.4{\%}) patients developed one or more spondylarthropathy-related manifestations without fulfilling any of the classification criteria. In patients satisfying ESSG criteria a significantly higher frequency of women (P = 0.03), of ocular and liver involvement (P = 0.01 and P = 0.03, respectively), and use of immunosuppressive drugs (P = 0.02) was observed. Conclusion: Our study shows a high prevalence of musculoskeletal manifestations in an inception cohort of IBD patients. The clinical spectrum is broader than that defined by spondylarthropathy criteria.",
keywords = "Crohn disease, Epidemiology, Extra-intestinal manifestations, Inflammatory bowel disease, Spondylarthropathy, Ulcerative colitis",
author = "C. Salvarani and Vlachonikolis, {I. G.} and {Van der Heijde}, {D. M.} and G. Fornaciari and P. Macchioni and M. Beltrami and I. Olivieri and {Di Gennaro}, F. and P. Politi and Stockbr{\"u}gger, {R. W.} and Russel, {M. G.}",
year = "2001",
doi = "10.1080/003655201317097173",
language = "English",
volume = "36",
pages = "1307--1313",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Musculoskeletal manifestations in a population-based cohort of inflammatory bowel disease patients

AU - Salvarani, C.

AU - Vlachonikolis, I. G.

AU - Van der Heijde, D. M.

AU - Fornaciari, G.

AU - Macchioni, P.

AU - Beltrami, M.

AU - Olivieri, I.

AU - Di Gennaro, F.

AU - Politi, P.

AU - Stockbrügger, R. W.

AU - Russel, M. G.

PY - 2001

Y1 - 2001

N2 - Background: Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in an inception cohort of European IBD patients. Methods: From 1 October 1991 to 30 September 1993, 202 IBD patients were diagnosed in three centres of two countries (Italy and The Netherlands) by means of a population-based inception cohort study. Of this group of patients, 160 (79%) were interviewed and examined by a rheumatologist and a gastroenterologist in the period June-September 1996. A total of 139/160 patients had an anteroposterior radiograph of the pelvis, and in 140/160 HLA-B27 was determined. Results: 53 (33.1%) of the 160 patients had experienced at least one musculoskeletal manifestation, 29 (18.1%) satisfied the European Spondylarthropathy Study Group (ESSG) criteria for spondylarthropathy and 5 (3.1%) satisfied the modified New York criteria for ankylosing spondylitis. However, 23 (14.4%) patients developed one or more spondylarthropathy-related manifestations without fulfilling any of the classification criteria. In patients satisfying ESSG criteria a significantly higher frequency of women (P = 0.03), of ocular and liver involvement (P = 0.01 and P = 0.03, respectively), and use of immunosuppressive drugs (P = 0.02) was observed. Conclusion: Our study shows a high prevalence of musculoskeletal manifestations in an inception cohort of IBD patients. The clinical spectrum is broader than that defined by spondylarthropathy criteria.

AB - Background: Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in an inception cohort of European IBD patients. Methods: From 1 October 1991 to 30 September 1993, 202 IBD patients were diagnosed in three centres of two countries (Italy and The Netherlands) by means of a population-based inception cohort study. Of this group of patients, 160 (79%) were interviewed and examined by a rheumatologist and a gastroenterologist in the period June-September 1996. A total of 139/160 patients had an anteroposterior radiograph of the pelvis, and in 140/160 HLA-B27 was determined. Results: 53 (33.1%) of the 160 patients had experienced at least one musculoskeletal manifestation, 29 (18.1%) satisfied the European Spondylarthropathy Study Group (ESSG) criteria for spondylarthropathy and 5 (3.1%) satisfied the modified New York criteria for ankylosing spondylitis. However, 23 (14.4%) patients developed one or more spondylarthropathy-related manifestations without fulfilling any of the classification criteria. In patients satisfying ESSG criteria a significantly higher frequency of women (P = 0.03), of ocular and liver involvement (P = 0.01 and P = 0.03, respectively), and use of immunosuppressive drugs (P = 0.02) was observed. Conclusion: Our study shows a high prevalence of musculoskeletal manifestations in an inception cohort of IBD patients. The clinical spectrum is broader than that defined by spondylarthropathy criteria.

KW - Crohn disease

KW - Epidemiology

KW - Extra-intestinal manifestations

KW - Inflammatory bowel disease

KW - Spondylarthropathy

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=17944383417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17944383417&partnerID=8YFLogxK

U2 - 10.1080/003655201317097173

DO - 10.1080/003655201317097173

M3 - Article

C2 - 11761022

AN - SCOPUS:17944383417

VL - 36

SP - 1307

EP - 1313

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 12

ER -